Literature DB >> 11342237

SeO(2) induces apoptosis with down-regulation of Bcl-2 and up-regulation of P53 expression in both immortal human hepatic cell line and hepatoma cell line.

Y Wei1, X Cao, Y Ou, J Lu, C Xing, R Zheng.   

Abstract

An immortal human hepatic cell line HL-7702 and human hepatoma cell line SMMC-7721 were treated with 3-30 microM SeO(2). SeO(2) at 30 microM markedly inhibited cell proliferation and viability, and prompted apoptosis of both normal hepatic and hepatoma cells after 48h treatment. SeO(2) could also down-regulate the Bcl-2 level, greatly in HL-7702 and slightly in SMMC-7721 cells, but up-regulate wild type P53 level a little in HL-7702 and significantly in SMMC-7721 cells. The Bcl-2/P53 value was closely correlated with the apoptotic rate as well as SeO(2) concentrations.

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Year:  2001        PMID： 11342237     DOI： 10.1016/s1383-5718(00)00149-2

Source DB:  PubMed          Journal:  Mutat Res        ISSN： 0027-5107            Impact factor:   2.433


  9 in total

1.  Apoptosis induced by selenomethionine and methioninase is superoxide mediated and p53 dependent in human prostate cancer cells.

Authors:  Rui Zhao; Frederick E Domann; Weixiong Zhong
Journal:  Mol Cancer Ther       Date:  2006-12       Impact factor: 6.261

2.  Selenite sensitizes mitochondrial permeability transition pore opening in vitro and in vivo: a possible mechanism for chemo-protection.

Authors:  Shani Shilo; Anna Aronis; Rita Komarnitsky; Oren Tirosh
Journal:  Biochem J       Date:  2003-02-15       Impact factor: 3.857

3.  Porcine serum can be biofortified with selenium to inhibit proliferation of three types of human cancer cells.

Authors:  Lv-Hui Sun; Jun-Gang Li; Hua Zhao; Jing Shi; Jia-Qiang Huang; Kang-Ning Wang; Xin-Jie Xia; Li Li; Xin Gen Lei
Journal:  J Nutr       Date:  2013-05-15       Impact factor: 4.798

4.  Expression of p53 enhances selenite-induced superoxide production and apoptosis in human prostate cancer cells.

Authors:  Rui Zhao; Nong Xiang; Frederick E Domann; Weixiong Zhong
Journal:  Cancer Res       Date:  2006-02-15       Impact factor: 12.701

5.  Sodium selenite induces apoptosis by generation of superoxide via the mitochondrial-dependent pathway in human prostate cancer cells.

Authors:  Nong Xiang; Rui Zhao; Weixiong Zhong
Journal:  Cancer Chemother Pharmacol       Date:  2008-04-01       Impact factor: 3.333

6.  Absence of p53 gene expression in selenium molecular prevention of chemically induced hepatocarcinogenesis in rats.

Authors:  Nasar Y Alwahaibi; Siti B Budin; Jamaludin H Mohamed
Journal:  Saudi J Gastroenterol       Date:  2011 Sep-Oct       Impact factor: 2.485

7.  Reduction of gene repair by selenomethionine with the use of single-stranded oligonucleotides.

Authors:  Timothy R Schwartz; Eric B Kmiec
Journal:  BMC Mol Biol       Date:  2007-01-26       Impact factor: 2.946

8.  Expression and Functional Analysis of the BCL2-Associated Agonist of Cell Death (BAD) Gene in the Sheep Ovary During the Reproductive Cycle.

Authors:  Xiaohan Cao; Xiangyu Wang; Lulu Lu; Xiaoyu Li; Ran Di; Xiaoyun He; Wenping Hu; Xianyin Zeng; Qiuyue Liu; Mingxing Chu
Journal:  Front Endocrinol (Lausanne)       Date:  2018-09-19       Impact factor: 5.555

9.  Selenium Nanoparticle Protection of Fibroblast Stress: Activation of ATF4 and Bcl-xL Expression.

Authors:  Stanley Chung; Amit K Roy; Thomas J Webster
Journal:  Int J Nanomedicine       Date:  2019-12-20
  9 in total

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