| Literature DB >> 11342226 |
J Mollerup1, S T Jørgensen, C Hougaard, E K Hoffmann.
Abstract
We report the identification of an EST encoding a murine cysteinyl leukotriene (mCysLT) receptor. LTD4, LTC4 and LTE4 but not LTB4 or various nucleotides activated Ca2+-evoked Cl- currents in mCysLT1 expressing Xenopus laevis oocytes. The response to LTD4 was blocked by MK-571, reduced by pretreatment with pertussis toxin (PTX), and was partly dependent on extracellular Ca2+. The identified murine CysLT1 receptor differs from the hCysLT1 receptor with regard to PTX sensitivity, receptor-mediated Ca2+ influx, and antagonist sensitivity.Entities:
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Year: 2001 PMID： 11342226 DOI： 10.1016/s0167-4781(00)00271-2
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002