Literature DB >> 1134219

Oxidative desaturation of alpha-linoleic, linoleic, and stearic acids by human liver microsomes.

I N de Gŏmez Dumm, R R Brenner.   

Abstract

The desaturation of stearic, linoleic, and alpha-linolenic acids by human liver microsomes were studied. The microsomes were isolated from liver biopsies obtained during operation. It was shown that human liver microsomes are able to desaturate 1-14-C-alpha-linoleic acid to octadeca-6,9,12,15,-telraenoic acid: 1-15-C-linoleic acid to gammalinolenic acid; and 1-14-C-stearic acid to oleic acid in the same system described in the rat. However, the desaturation activity obtained was low compared to other mammals. This effect was attributed to fasting, pre-medication, or the anaesthesia.

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Year:  1975        PMID： 1134219     DOI： 10.1007/bf02532451

Source DB:  PubMed          Journal:  Lipids        ISSN： 0024-4201            Impact factor:   1.880


  8 in total

1.  Determination of serum proteins by means of the biuret reaction.

Authors:  A G GORNALL; C J BARDAWILL; M M DAVID
Journal:  J Biol Chem       Date:  1949-02       Impact factor: 5.157

2.  Influence of dietary protein on 6- and 9-desaturation of fatty acids in rats of different ages and in different seasons.

Authors:  R O Peluffo; R R Brenner
Journal:  J Nutr       Date:  1974-07       Impact factor: 4.798

3.  Electron-transfer mechanism associated with fatty acid desaturation catalyzed by liver microsomes.

Authors:  N Oshino; Y Imai; R Sato
Journal:  Biochim Biophys Acta       Date:  1966-10-17

4.  Circadian rhythm of fatty acid desaturation in mouse liver.

Authors:  S M Actis Dato; A Catala; R R Brenner
Journal:  Lipids       Date:  1973-01       Impact factor: 1.880

5.  Effect of diet on linoleic acid desaturation and on some enzymes of carbohydrate metabolism.

Authors:  I N De Gomez Dumm; M J De Alaniz; R R Brenner
Journal:  J Lipid Res       Date:  1970-03       Impact factor: 5.922

6.  Differential responses to fasting and subsequent feeding by microsomal systems of rat liver: 6- and 9-desaturation of fatty acids.

Authors:  C A Inkpen; R A Harris; F W Quackenbush
Journal:  J Lipid Res       Date:  1969-05       Impact factor: 5.922

7.  Effect of saturated and unsaturated fatty acids on the desaturation in vitro of palmitic, stearic, oleic, linoleic, and linolenic acids.

Authors:  R R Brenner; R O Peluffo
Journal:  J Biol Chem       Date:  1966-11-25       Impact factor: 5.157

8.  Oxidative desaturation of eicosa-8,11-dienoic acid to eicosa-5,8,11-trienoic acid: comparison of different diets on oxidative desaturation at the 5,6 and 6,7 positions.

Authors:  J C Castuma; A Catala; R R Brenner
Journal:  J Lipid Res       Date:  1972-11       Impact factor: 5.922
  8 in total
  17 in total

Review 1.  Omega-3 fatty acids: their beneficial role in cardiovascular health.

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Journal:  Can Fam Physician       Date:  2006-06       Impact factor: 3.275

Review 2.  Polyunsaturated fatty acids and peripheral artery disease.

Authors:  S Marlene Grenon; Millie Hughes-Fulford; Joseph Rapp; Michael S Conte
Journal:  Vasc Med       Date:  2012-02       Impact factor: 3.239

3.  Effects of age and dietary essential fatty acids on desaturase activities and on fatty acid composition of liver microsomal phospholipids of adult rats.

Authors:  L Ulmann; J P Blond; C Maniongui; J P Poisson; G Durand; J Bézard; G Pascal
Journal:  Lipids       Date:  1991-02       Impact factor: 1.880

Review 4.  Nutritional cancer risks derived from energy and fat.

Authors:  A P Simopoulos
Journal:  Med Oncol Tumor Pharmacother       Date:  1987

5.  Phospholipid content and fatty acid composition of human heart.

Authors:  G Rocquelin; L Guenot; P O Astorg; M David
Journal:  Lipids       Date:  1989-09       Impact factor: 1.880

Review 6.  Pathways of polyunsaturated fatty acid utilization: implications for brain function in neuropsychiatric health and disease.

Authors:  Joanne J Liu; Pnina Green; J John Mann; Stanley I Rapoport; M Elizabeth Sublette
Journal:  Brain Res       Date:  2014-12-08       Impact factor: 3.252

7.  Age-related changes in delta 6 and delta 5 desaturase activities in rat liver microsomes.

Authors:  C Maniongui; J P Blond; L Ulmann; G Durand; J P Poisson; J Bézard
Journal:  Lipids       Date:  1993-04       Impact factor: 1.880

8.  Incorporation and metabolic conversion of saturated and unsaturated fatty acids in SK-Hep1 human hepatoma cells in culture.

Authors:  C A Marra; M J de Alaniz
Journal:  Mol Cell Biochem       Date:  1992-11-18       Impact factor: 3.396

9.  Characterization of gamma-linolenic acid in Ribes seed.

Authors:  H Traitler; H Winter; U Richli; Y Ingenbleek
Journal:  Lipids       Date:  1984-12       Impact factor: 1.880

10.  Arachidonic and docosahexaenoic acids are biosynthesized from their 18-carbon precursors in human infants.

Authors:  N Salem; B Wegher; P Mena; R Uauy
Journal:  Proc Natl Acad Sci U S A       Date:  1996-01-09       Impact factor: 11.205
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