F T Brandt1, C D Albuquerque, F R Lorenzato. 1. Division of Urogynecology, Universidade Federal de Pernam, Parnamirim-Recife-Pe, CEP, Brazil. fcbrandt@elogica.com.br
Abstract
BACKGROUND: About 1-5% of female babies are born with Müllerian duct abnormalities such as Mayer-Rokitansky-Küster-Hauser syndrome, urogenital sinus, and cloacal malformation. In some intersex cases the urethra and vagina both empty into a urogenital sinus. One major issue in single-stage surgical reconstruction of large urethral defects is tissue availability. AIM: To investigate the usefulness of amnion grafts in female urethral reconstruction. METHODS: This is a prospective cohort study describing the use of amnion grafts for urethral reconstruction in 8 patients with ambiguous genitalia associated with low or mid-portion urethrovaginal confluence or vaginal agenesis with low external urethral meatus implantation. RESULTS: The procedure was felt to be easy, quick and effective for appropriate restoration of both the function and the cosmetics of the lower urogenital tract. CONCLUSIONS: Amnion grafts add a valuable option to the surgical armamentarium and offers potential advantages for urogenital reconstructive surgery.
BACKGROUND: About 1-5% of female babies are born with Müllerian duct abnormalities such as Mayer-Rokitansky-Küster-Hauser syndrome, urogenital sinus, and cloacal malformation. In some intersex cases the urethra and vagina both empty into a urogenital sinus. One major issue in single-stage surgical reconstruction of large urethral defects is tissue availability. AIM: To investigate the usefulness of amnion grafts in female urethral reconstruction. METHODS: This is a prospective cohort study describing the use of amnion grafts for urethral reconstruction in 8 patients with ambiguous genitalia associated with low or mid-portion urethrovaginal confluence or vaginal agenesis with low external urethral meatus implantation. RESULTS: The procedure was felt to be easy, quick and effective for appropriate restoration of both the function and the cosmetics of the lower urogenital tract. CONCLUSIONS: Amnion grafts add a valuable option to the surgical armamentarium and offers potential advantages for urogenital reconstructive surgery.
Authors: Jan Adamowicz; Marta Pokrywczyńska; Jakub Tworkiewicz; Tomasz Kowalczyk; Shane V van Breda; Dominik Tyloch; Tomasz Kloskowski; Magda Bodnar; Joanna Skopinska-Wisniewska; Andrzej Marszałek; Malgorzata Frontczak-Baniewicz; Tomasz A Kowalewski; Tomasz Drewa Journal: PLoS One Date: 2016-01-14 Impact factor: 3.240