Literature DB >> 11341411

The management of osteoporosis.

A B Stephen1, W A Wallace.   

Abstract

Osteoporosis poses a significant orthopaedic problem of epidemic proportions. Clear guidelines for the management of osteoporosis presenting early or late are still being debated. Several recommendations, however, are now generally accepted. Measurements of BMD should be taken if the diagnosis is in doubt or as an adjunct to encourage patient compliance with treatment. Those with multiple risk factors and who are under the age of 65 years would benefit from a scan. Those with previous fractures and no obvious risk factors should also be sent for DXA assessment. The elderly with fractures and multiple risk factors do not need scanning and can normally be started on treatment. Mass population screening is not cost-effective. Prevention strategies should be targeted at high-risk patients and not offered to everyone. In the perimenopausal woman HRT is the first line of treatment and prevention, along with changes in lifestyle. Tibolone may be an option for those who find cyclical bleeding unacceptable. In the elderly, institutionalised patient, calcium and vitamin-D supplements should be considered to replace depleted levels, particularly for secondary prevention. Postmenopausal women with multiple risk factors and at least one insufficiency fracture should be treated. The most likely pharmacological agent will be a bisphosphonate with supplemental calcium if indicated. Each hospital should have a recognised link person through whom referrals can be channelled, either a clinical nurse specialist or physician. A protocol for treatment should be agreed locally and publicised among the primary health-care groups. The first step of identification of high-risk patients is most often in fracture clinics. Standardised letters attached to the clinic note to general practitioners are an easy way of 'getting these patients into the system'.

Entities:  

Mesh:

Year:  2001        PMID: 11341411     DOI: 10.1302/0301-620x.83b3.12196

Source DB:  PubMed          Journal:  J Bone Joint Surg Br        ISSN: 0301-620X


  6 in total

1.  Multinational survey of osteoporotic fracture management.

Authors:  Karsten E Dreinhöfer; Mary Anderson; Jean-Marc Féron; Antonio Herrera; Robert Hube; Olof Johnell; Lars Lidgren; Kim Miles; Umberto Tarantino; Hamish Simpson; W Angus Wallace
Journal:  Osteoporos Int       Date:  2004-09-16       Impact factor: 4.507

2.  Sequential multiple insufficiency fractures around knee over 6 months in a patient with primary osteoporosis.

Authors:  Masaru Kadowaki; Shinji Imade; Suguru Kuwata; Yuji Uchio
Journal:  Eur J Orthop Surg Traumatol       Date:  2012-02-03

3.  Bilateral atypical insufficiency fractures of the proximal tibia and a unilateral distal femoral fracture associated with long-term intravenous bisphosphonate therapy: a case report.

Authors:  Arjuna Mahinda Imbuldeniya; Natasha Jiwa; John Paul Murphy
Journal:  J Med Case Rep       Date:  2012-02-06

4.  The nucleocytoplasmic shuttling protein CIZ reduces adult bone mass by inhibiting bone morphogenetic protein-induced bone formation.

Authors:  Mikihiko Morinobu; Tetsuya Nakamoto; Kazunori Hino; Kunikazu Tsuji; Zhong-Jian Shen; Kazuhisa Nakashima; Akira Nifuji; Haruyasu Yamamoto; Hisamaru Hirai; Masaki Noda
Journal:  J Exp Med       Date:  2005-03-21       Impact factor: 14.307

5.  Trends Analysis of rhBMP2 Utilization in Single-Level Anterior Lumbar Interbody Fusion in the United States.

Authors:  Lifeng Lao; Jeremiah R Cohen; Zorica Buser; Darrel S Brodke; S Tim Yoon; Jim A Youssef; Jong-Beom Park; Hans-Joerg Meisel; Jeffrey C Wang
Journal:  Global Spine J       Date:  2017-05-16

6.  Brachial-ankle pulse wave velocity is associated with the risk of osteoporosis: a cross-sectional evidence from a Chinese community-based cohort.

Authors:  Kun Tang; Qiao Zhang; Nianchun Peng; Ying Hu; Shujing Xu; Miao Zhang; Rui Wang; Lixin Shi
Journal:  J Orthop Surg Res       Date:  2021-01-04       Impact factor: 2.359

  6 in total

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