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Literature DB >> 11340326

Dendritic cells as regulators of the immune response to inhaled allergen: recent findings in animal models of asthma.

B N Lambrecht¹, H C Hoogsteden, R A Pauwels.

Abstract

Antigen-presenting dendritic cells are essential for the recognition and presentation of allergens to the cells of the immune system. Airway dendritic cells capture allergen in the mucosa and present it to naive T cells after migration into the draining lymph nodes. In this review article, we discuss the most recent findings from animal models of asthma, which highlight an essential role for these cells in the induction and maintenance of eosinophilic airway inflammation. This increasing knowledge might lead to the identification of new targets for the prevention and therapy of asthma. Copyright 2001 S. Karger AG, Basel

Entities: Disease

Mesh：

Substances：
Allergens
Ovalbumin

Year: 2001 PMID： 11340326 DOI： 10.1159/000053778

Source DB: PubMed Journal: Int Arch Allergy Immunol ISSN： 1018-2438 Impact factor: 2.749

Keyword Cloud
Cited

7 in total

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2. Intranasal exposure to bacterial superantigens induces airway inflammation in HLA class II transgenic mice.

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Journal: Infect Immun Date: 2006-02 Impact factor: 3.441

3. The effects of targeted deletion of cannabinoid receptors CB1 and CB2 on intranasal sensitization and challenge with adjuvant-free ovalbumin.

Authors: Barbara L F Kaplan; Jody E Lawver; Peer W F Karmaus; Thitirat Ngaotepprutaram; Neil P Birmingham; Jack R Harkema; Norbert E Kaminski
Journal: Toxicol Pathol Date: 2010-02-26 Impact factor: 1.902

4. The lung cytokine microenvironment influences molecular events in the lymph nodes during Th1 and Th2 respiratory mucosal sensitization to antigen in vivo.

Authors: S A Ritz; M J Cundall; B U Gajewska; F K Swirski; R E Wiley; D Alvarez; A J Coyle; M R Stampfli; M Jordana
Journal: Clin Exp Immunol Date: 2004-11 Impact factor: 4.330

Dendritic cells as regulators of the immune response to inhaled allergen: recent findings in animal models of asthma.

1. Bordetella bronchiseptica persists in the nasal cavities of mice and triggers early delivery of dendritic cells in the lymph nodes draining the lower and upper respiratory tract.

2. Intranasal exposure to bacterial superantigens induces airway inflammation in HLA class II transgenic mice.

3. The effects of targeted deletion of cannabinoid receptors CB1 and CB2 on intranasal sensitization and challenge with adjuvant-free ovalbumin.

4. The lung cytokine microenvironment influences molecular events in the lymph nodes during Th1 and Th2 respiratory mucosal sensitization to antigen in vivo.

Review 5. Thymic stromal lymphopoietin, OX40-ligand, and interleukin-25 in allergic responses.

6. IL-23 plays a significant role in the augmentation of particulate matter-mediated allergic airway inflammation.

7. The Association between Tobacco Smoke and Serum Immunoglobulin E Levels in Korean Adults.