| Literature DB >> 11340205 |
M Iino1, K Goto, W Kakegawa, H Okado, M Sudo, S Ishiuchi, A Miwa, Y Takayasu, I Saito, K Tsuzuki, S Ozawa.
Abstract
Glial cells express a variety of neurotransmitter receptors. Notably, Bergmann glial cells in the cerebellum have Ca2+-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs) assembled without the GluR2 subunit. To elucidate the role of these Ca2+-permeable AMPARs, we converted them into Ca2+-impermeable receptors by adenoviral-mediated delivery of the GluR2 gene. This conversion retracted the glial processes ensheathing synapses on Purkinje cell dendritic spines and retarded the removal of synaptically released glutamate. Furthermore, it caused multiple innervation of Purkinje cells by the climbing fibers. Thus, the glial Ca2+-permeable AMPARs are indispensable for proper structural and functional relations between Bergmann glia and glutamatergic synapses.Entities:
Mesh：
Substances：
Year: 2001 PMID： 11340205 DOI： 10.1126/science.1058827
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728