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Literature DB >> 11339973

Role of 5-HT(2C) receptors in the control of central dopamine function.

V Di Matteo¹, A De Blasi, C Di Giulio, E Esposito.

Abstract

Substantial evidence suggests that the functional status of the mesocorticolimbic dopamine (DA) system originating in the ventral tegmental area is under a phasic and tonic inhibitory control by the 5-HT system that acts by stimulating 5-HT(2C) receptor subtypes. Indeed, electrophysiological and biochemical data demonstrate that 5-HT(2C) receptor agonists decrease, whereas 5-HT(2C) receptor antagonists enhance, mesocorticolimbic DA function. However, 5-HT(2C) receptors do not appear to play a relevant role in the control of the nigrostriatal DA system originating in the substantia nigra pars compacta. In this article, the role of 5-HT(2C) receptors in the control of brain DA function will be reviewed, and the search for new therapies for neuropsychiatric disorders, such as depression, schizophrenia and drug addiction, based on these findings will be discussed.

Entities: Chemical Disease

Mesh：

Substances：

Year: 2001 PMID： 11339973 DOI： 10.1016/s0165-6147(00)01688-6

Source DB: PubMed Journal: Trends Pharmacol Sci ISSN： 0165-6147 Impact factor: 14.819

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Cited

55 in total

1. Synaptic multiprotein complexes associated with 5-HT(2C) receptors: a proteomic approach.

Authors: Carine Bécamel; Gérard Alonso; Nathalie Galéotti; Emmanuelle Demey; Patrick Jouin; Christoph Ullmer; Aline Dumuis; Joël Bockaert; Philippe Marin
Journal: EMBO J Date: 2002-05-15 Impact factor: 11.598

2. Role of serotonin in cocaine effects in mice with reduced dopamine transporter function.

Authors: Yolanda Mateo; Evgeny A Budygin; Carrie E John; Sara R Jones
Journal: Proc Natl Acad Sci U S A Date: 2003-12-22 Impact factor: 11.205

3. Serotonin (5-HT) precursor loading with 5-hydroxy-l-tryptophan (5-HTP) reduces locomotor activation produced by (+)-amphetamine in the rat.

Authors: Michael H Baumann; Zakia Williams; Dorota Zolkowska; Richard B Rothman
Journal: Drug Alcohol Depend Date: 2010-11-10 Impact factor: 4.492

10. Blockade of serotonin 5-HT1B and 5-HT2A receptors suppresses the induction of locomotor activity by 5-HT reuptake inhibitors, citalopram and fluvoxamine, in NMRI mice exposed to a novel environment: a comparison to other 5-HT receptor subtypes.

Authors: Mark J Millan; Sylvie Veiga; Sylvie Girardon; Mauricette Brocco
Journal: Psychopharmacology (Berl) Date: 2003-04-30 Impact factor: 4.530

Role of 5-HT(2C) receptors in the control of central dopamine function.

1. Synaptic multiprotein complexes associated with 5-HT(2C) receptors: a proteomic approach.

2. Role of serotonin in cocaine effects in mice with reduced dopamine transporter function.

3. Serotonin (5-HT) precursor loading with 5-hydroxy-l-tryptophan (5-HTP) reduces locomotor activation produced by (+)-amphetamine in the rat.

Review 4. Mechanism of action of atypical antipsychotic drugs and the neurobiology of schizophrenia.

Review 5. Serotonin2C receptors and drug addiction: focus on cocaine.

6. Dorsal raphe neurons signal reward through 5-HT and glutamate.

7. Serotonin-2C and -2a receptor co-expression on cells in the rat medial prefrontal cortex.

Review 8. Multiple controls exerted by 5-HT2C receptors upon basal ganglia function: from physiology to pathophysiology.

9. Role of 5-HT receptor mechanisms in sub-chronic PCP-induced reversal learning deficits in the rat.

10. Blockade of serotonin 5-HT1B and 5-HT2A receptors suppresses the induction of locomotor activity by 5-HT reuptake inhibitors, citalopram and fluvoxamine, in NMRI mice exposed to a novel environment: a comparison to other 5-HT receptor subtypes.