PURPOSE: This study was undertaken with a view to establishing the occurrence of neuropsychiatric disorders in the 22q11 deletion syndrome. METHODS: Thirty-two children and young adults with genetically confirmed 22q11 deletion were given comprehensive neuropsychiatric assessments. RESULTS: Altogether, 56% had a neuropsychiatric disorder. Only 6% were of normal IQ and free of physchiatric disorder. Attention-deficit/hyperactivity disorder was diagnosed in 44% and 31% had an autism spectrum problem. In 16% criteria for both these diagnoses were met. Fifty-three percent had mental retardation, often with a test-profile suggesting a nonverbal learning disorder. CONCLUSION: The findings imply that a majority of children and adolescents with 22q11 deletion syndrome are in need of neuropsychiatric assessment and intervention.
PURPOSE: This study was undertaken with a view to establishing the occurrence of neuropsychiatric disorders in the 22q11 deletion syndrome. METHODS: Thirty-two children and young adults with genetically confirmed 22q11 deletion were given comprehensive neuropsychiatric assessments. RESULTS: Altogether, 56% had a neuropsychiatric disorder. Only 6% were of normal IQ and free of physchiatric disorder. Attention-deficit/hyperactivity disorder was diagnosed in 44% and 31% had an autism spectrum problem. In 16% criteria for both these diagnoses were met. Fifty-three percent had mental retardation, often with a test-profile suggesting a nonverbal learning disorder. CONCLUSION: The findings imply that a majority of children and adolescents with 22q11 deletion syndrome are in need of neuropsychiatric assessment and intervention.
Authors: Mechteld L C Hoogendoorn; Jacob A S Vorstman; Gholam R Jalali; Jean-Paul Selten; Richard J Sinke; Beverly S Emanuel; René S Kahn Journal: Schizophr Res Date: 2007-10-26 Impact factor: 4.939
Authors: Carrie E Bearden; David C Glahn; Agatha D Lee; Ming-Chang Chiang; Theo G M van Erp; Tyrone D Cannon; Allan L Reiss; Arthur W Toga; Paul M Thompson Journal: Biol Psychol Date: 2008-02-23 Impact factor: 3.251
Authors: C A Montojo; M Jalbrzikowski; E Congdon; S Domicoli; C Chow; C Dawson; K H Karlsgodt; R M Bilder; C E Bearden Journal: Cereb Cortex Date: 2013-10-31 Impact factor: 5.357