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Literature DB >> 11339349

Immune responses to DNA in normal and aberrant immunity.

Abstract

Because of structural microheterogeneity, DNA can exert powerful effects that lead to immune system activation as well as antibody induction. These activating effects resemble those ofendotoxin and result from sequences that occur much more commonly in bacterial DNA than in mammalian DNA. In contrast, mammalian DNA can inhibit the response to bacterial DNA as well as other stimuli and may serve a counterregulatory role during infection. The recognition of the immune effects of DNA is relevant to the pathogenesis of a variety of infectious and inflammatory diseases including systemic lupus erythematosus, a prototypic autoimmune disease characterized by anti-DNA autoantibodies.

Entities: Chemical

Mesh：

Substances：

Year: 2000 PMID： 11339349 DOI： 10.1385/IR:22:2-3:119

Source DB: PubMed Journal: Immunol Res ISSN： 0257-277X Impact factor: 4.505

28 in total

1. Influence of backbone chemistry on immune activation by synthetic oligonucleotides.

Authors: D S Pisetsky; C F Reich
Journal: Biochem Pharmacol Date: 1999-12-15 Impact factor: 5.858

2. Sequence motifs in adenoviral DNA block immune activation by stimulatory CpG motifs.

Authors: A M Krieg; T Wu; R Weeratna; S M Efler; L Love-Homan; L Yang; A K Yi; D Short; H L Davis
Journal: Proc Natl Acad Sci U S A Date: 1998-10-13 Impact factor: 11.205

3. The influence of DNA sequence on the immunostimulatory properties of plasmid DNA vectors.

Authors: M K Wloch; S Pasquini; H C Ertl; D S Pisetsky
Journal: Hum Gene Ther Date: 1998-07-01 Impact factor: 5.695

4. Patterns of heavy and light chain utilization in the antibody response to single-stranded bacterial DNA in normal human subjects and patients with systemic lupus erythematosus.

Authors: C R Robertson; G S Gilkeson; M M Ward; D S Pisetsky
Journal: Clin Immunol Immunopathol Date: 1992-01

Review 5. Immune activation by bacterial DNA: a new genetic code.

Authors: D S Pisetsky
Journal: Immunity Date: 1996-10 Impact factor: 31.745

Review 6. Antibodies to DNA. A perspective.

Authors: W Emlen; D S Pisetsky; R P Taylor
Journal: Arthritis Rheum Date: 1986-12

7. Deficient expression of antibodies specific for bacterial DNA by patients with systemic lupus erythematosus.

Authors: D S Pisetsky; D M Drayton
Journal: Proc Assoc Am Physicians Date: 1997-05

8. Inhibition of murine macrophage IL-12 production by natural and synthetic DNA.

Authors: D S Pisetsky; C F Reich
Journal: Clin Immunol Date: 2000-09 Impact factor: 3.969

9. The influence of DNA structure on the in vitro stimulation of murine lymphocytes by natural and synthetic polynucleotide antigens.

Authors: J P Messina; G S Gilkeson; D S Pisetsky
Journal: Cell Immunol Date: 1993-03 Impact factor: 4.868

Review 5. Opportunities and challenges for the clinical translation of structured DNA assemblies as gene therapeutic delivery and vaccine vectors.

Authors: Marina A Dobrovolskaia; Mark Bathe
Journal: Wiley Interdiscip Rev Nanomed Nanobiotechnol Date: 2020-07-15

5 in total

Immune responses to DNA in normal and aberrant immunity.

1. Influence of backbone chemistry on immune activation by synthetic oligonucleotides.

2. Sequence motifs in adenoviral DNA block immune activation by stimulatory CpG motifs.

3. The influence of DNA sequence on the immunostimulatory properties of plasmid DNA vectors.

4. Patterns of heavy and light chain utilization in the antibody response to single-stranded bacterial DNA in normal human subjects and patients with systemic lupus erythematosus.

Review 5. Immune activation by bacterial DNA: a new genetic code.

Review 6. Antibodies to DNA. A perspective.

7. Deficient expression of antibodies specific for bacterial DNA by patients with systemic lupus erythematosus.

8. Inhibition of murine macrophage IL-12 production by natural and synthetic DNA.

9. The influence of DNA structure on the in vitro stimulation of murine lymphocytes by natural and synthetic polynucleotide antigens.

10. Induction of anti-double stranded DNA antibodies in normal mice by immunization with bacterial DNA.

1. The role of macrophages in the in vitro generation of extracellular DNA from apoptotic and necrotic cells.

2. The role of microparticles in the generation of immune complexes in murine lupus.

3. Systemic Lupus Erythematosus: Definitions, Contexts, Conflicts, Enigmas.

Review 4. Cooperation of Oligodeoxynucleotides and Synthetic Molecules as Enhanced Immune Modulators.

Review 5. Opportunities and challenges for the clinical translation of structured DNA assemblies as gene therapeutic delivery and vaccine vectors.