Literature DB >> 11338932

Cationic polymers for gene delivery: designs for overcoming barriers to systemic administration.

S J Hwang1, M E Davis.   

Abstract

Cationic, polymer-based delivery systems have faced limitations in the systemic delivery of therapeutic gene drugs due to difficulties in formulation, in vivo stabilization, toxicity and low transfection efficiencies. Strategies for overcoming some of these barriers have utilized knowledge gained from the fields of colloidal stabilization and protein trafficking. This review highlights recent efforts in polycation preparations that include the development of new polymers for gene delivery, the modification of traditional polycations with hydrophilic polymers for salt and serum stability and the addition of bioactive functionalities to polymers for enhanced intracellular trafficking. These studies have resulted in polymer/DNA composites with increased stability and delivery efficiencies.

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Year:  2001        PMID： 11338932

Source DB:  PubMed          Journal:  Curr Opin Mol Ther        ISSN： 1464-8431


  16 in total

1.  Cross-linked polymeric nanogel formulations of 5'-triphosphates of nucleoside analogues: role of the cellular membrane in drug release.

Authors:  Serguei V Vinogradov; Ekta Kohli; Arin D Zeman
Journal:  Mol Pharm       Date:  2005 Nov-Dec       Impact factor: 4.939

Review 2.  Nonviral gene delivery: principle, limitations, and recent progress.

Authors:  Mohammed S Al-Dosari; Xiang Gao
Journal:  AAPS J       Date:  2009-10-16       Impact factor: 4.009

Review 3.  Polymeric nanoparticles: potent vectors for vaccine delivery targeting cancer and infectious diseases.

Authors:  Azam Bolhassani; Shabnam Javanzad; Tayebeh Saleh; Mehrdad Hashemi; Mohammad Reza Aghasadeghi; Seyed Mehdi Sadat
Journal:  Hum Vaccin Immunother       Date:  2013-10-15       Impact factor: 3.452

Review 4.  DNA-based therapeutics and DNA delivery systems: a comprehensive review.

Authors:  Siddhesh D Patil; David G Rhodes; Diane J Burgess
Journal:  AAPS J       Date:  2005-04-08       Impact factor: 4.009

5.  Neuron-targeted copolymers with sheddable shielding blocks synthesized using a reducible, RAFT-ATRP double-head agent.

Authors:  Hua Wei; Joan G Schellinger; David S H Chu; Suzie H Pun
Journal:  J Am Chem Soc       Date:  2012-10-01       Impact factor: 15.419

6.  Self-assembled micellar aggregates based monomethoxyl poly(ethylene glycol)-b-poly(ε-caprolactone)-b-poly(aminoethyl methacrylate) triblock copolymers as efficient gene delivery vectors.

Authors:  Ming Ma; Feng Li; Xiu-hong Liu; Zhe-fan Yuan; Fu-jie Chen; Ren-xi Zhuo
Journal:  J Mater Sci Mater Med       Date:  2010-09-21       Impact factor: 3.896

Review 7.  Gold nanoparticles for biology and medicine.

Authors:  David A Giljohann; Dwight S Seferos; Weston L Daniel; Matthew D Massich; Pinal C Patel; Chad A Mirkin
Journal:  Angew Chem Int Ed Engl       Date:  2010-04-26       Impact factor: 15.336

8.  HPMA-oligolysine copolymers for gene delivery: optimization of peptide length and polymer molecular weight.

Authors:  Russell N Johnson; David S H Chu; Julie Shi; Joan G Schellinger; Peter M Carlson; Suzie H Pun
Journal:  J Control Release       Date:  2011-07-14       Impact factor: 9.776

9.  DNA as therapeutics; an update.

Authors:  P Saraswat; R R Soni; A Bhandari; B P Nagori
Journal:  Indian J Pharm Sci       Date:  2009-09       Impact factor: 0.975

10.  Effects of the incorporation of a hydrophobic middle block into a PEG-polycation diblock copolymer on the physicochemical and cell interaction properties of the polymer-DNA complexes.

Authors:  Rahul Sharma; Jae-Sung Lee; Ryan C Bettencourt; Chuan Xiao; Stephen F Konieczny; You-Yeon Won
Journal:  Biomacromolecules       Date:  2008-10-23       Impact factor: 6.988
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