Literature DB >> 11336749

CD8+ T lymphocytes protect SCID mice against Encephalitozoon cuniculi infection.

P Braunfuchsová1, J Salát, J Kopecký.   

Abstract

Microsporidia are obligate intracellular parasites that cause opportunistic infections in immunocompromised patients. The role of two main T cell subsets in anti-microsporidial immunity has been studied using an Encephalitozoon cuniculi-severe combined immunodeficient (SCID) mouse model. Whereas SCID mice reconstituted with CD4+ T lymphocyte-depleted naive BALB/c splenocytes resolved the infection, adoptive transfer of CD8+ T cell-depleted splenocytes failed to protect the animals against a lethal E. cuniculi infection. Splenocytes from E. cuniculi-immune mice specifically killed syngeneic infected macrophages in a short-term 51Cr-release assay. These results suggest the crucial role of cytotoxic T lymphocytes in the protection against E. cuniculi infection.

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Mesh：

Year:  2001        PMID： 11336749     DOI： 10.1016/s0020-7519(01)00134-5

Source DB:  PubMed          Journal:  Int J Parasitol        ISSN： 0020-7519            Impact factor:   3.981


  10 in total

1.  Pure CD4+ T lymphocytes fail to protect perorally infected SCID mice from lethal microsporidiosis caused by Encephalitozoon cuniculi.

Authors:  Jirí Salát; Helena Horká; Bohumil Sak; Jan Kopecký
Journal:  Parasitol Res       Date:  2006-11       Impact factor: 2.289

2.  MyD88-dependent pathway is essential for the innate immunity to Enterocytozoon bieneusi.

Authors:  Q Zhang; X Feng; W Nie; D T Golenbock; H Mayanja-Kizza; S Tzipori; H Feng
Journal:  Parasite Immunol       Date:  2011-04       Impact factor: 2.280

Review 3.  Effector CD8 T cell immunity in microsporidial infection: a lone defense mechanism.

Authors:  Magali M Moretto; Danielle I Harrow; Imtiaz A Khan
Journal:  Semin Immunopathol       Date:  2015-04-10       Impact factor: 9.623

4.  Lack of interleukin-12 in p40-deficient mice leads to poor CD8+ T-cell immunity against Encephalitozoon cuniculi infection.

Authors:  Magali M Moretto; Elizabeth M Lawlor; Imtiaz A Khan
Journal:  Infect Immun       Date:  2010-03-22       Impact factor: 3.441

5.  Chronic Infections in Mammals Due to Microsporidia.

Authors:  Bohumil Sak; Martin Kváč
Journal:  Exp Suppl       Date:  2022

6.  Immune Response to Microsporidia.

Authors:  Magali M Moretto; Imtiaz A Khan
Journal:  Exp Suppl       Date:  2022

7.  Aging mice exhibit a functional defect in mucosal dendritic cell response against an intracellular pathogen.

Authors:  Magali M Moretto; Elizabeth M Lawlor; Imtiaz A Khan
Journal:  J Immunol       Date:  2008-12-01       Impact factor: 5.422

8.  Diabetes mellitus increases the susceptibility to encephalitozoonosis in mice.

Authors:  Aldo Francisco Neto; Paulo Ricardo Dell'Armelina Rocha; Elizabeth Christina Perez; José Guilherme Xavier; Giovani Bravin Peres; Diva Denelle Spadacci-Morena; Anuska Marcelino Alvares-Saraiva; Maria Anete Lallo
Journal:  PLoS One       Date:  2017-11-01       Impact factor: 3.240

9.  Cyclophosphamide Treatment Mimics Sub-Lethal Infections With Encephalitozoon intestinalis in Immunocompromised Individuals.

Authors:  Maria Lucia Costa de Moura; Anuska Marcelino Alvares-Saraiva; Elizabeth Cristina Pérez; José Guilherme Xavier; Diva Denelle Spadacci-Morena; Carla Renata Serantoni Moysés; Paulo Ricardo Dell'Armelina Rocha; Maria Anete Lallo
Journal:  Front Microbiol       Date:  2019-09-25       Impact factor: 5.640

10.  Latent microsporidiosis caused by Encephalitozoon cuniculi in immunocompetent hosts: a murine model demonstrating the ineffectiveness of the immune system and treatment with albendazole.

Authors:  Michaela Kotkova; Bohumil Sak; Dana Kvetonova; Martin Kvac
Journal:  PLoS One       Date:  2013-04-11       Impact factor: 3.240
  10 in total

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