OBJECTIVE: To examine the use of antibiotic prophylaxis in cesarean section in different countries and in relation to a reference regimen. METHOD: Fifty consecutive cesarean sections performed in eight centers in five countries were surveyed. Data from each center were compared to a regimen recommended by the Cochrane Collaboration (one dose of ampicillin or cefazolin administered to all women shortly before the procedure or immediately after cord clamping) using logistic regression with adjustment for procedure type. RESULT: Prophylaxis was used widely, but only four centers administered prophylaxis to all women. Ampicillin and cefazolin were the principal antibiotics used, but broad-spectrum agents and multidrug regimens were also used commonly. Only two centers reliably administered the antibiotic at the appropriate time. The majority of women received only one dose of antibiotic in only three centers. CONCLUSION: The use of antibiotic prophylaxis in cesarean section was variable and often at odds with published recommendations.
OBJECTIVE: To examine the use of antibiotic prophylaxis in cesarean section in different countries and in relation to a reference regimen. METHOD: Fifty consecutive cesarean sections performed in eight centers in five countries were surveyed. Data from each center were compared to a regimen recommended by the Cochrane Collaboration (one dose of ampicillin or cefazolin administered to all women shortly before the procedure or immediately after cord clamping) using logistic regression with adjustment for procedure type. RESULT: Prophylaxis was used widely, but only four centers administered prophylaxis to all women. Ampicillin and cefazolin were the principal antibiotics used, but broad-spectrum agents and multidrug regimens were also used commonly. Only two centers reliably administered the antibiotic at the appropriate time. The majority of women received only one dose of antibiotic in only three centers. CONCLUSION: The use of antibiotic prophylaxis in cesarean section was variable and often at odds with published recommendations.
Authors: Cynthia Cordero; Rachel Delino; L Jeyaseelan; Mary Ann Lansang; Juan M Lozano; Shuba Kumar; Socorro Moreno; Merle Pietersen; Jose Quirino; Visanu Thamlikitkul; Vivian A Welch; Jacqueline Tetroe; Aleida Ter Kuile; Ian D Graham; Jeremy Grimshaw; Vic Neufeld; George Wells; Peter Tugwell Journal: Bull World Health Organ Date: 2008-07 Impact factor: 9.408
Authors: R F Lamont; J D Sobel; J P Kusanovic; E Vaisbuch; S Mazaki-Tovi; S K Kim; N Uldbjerg; R Romero Journal: BJOG Date: 2011-01 Impact factor: 6.531
Authors: David J Henderson-Smart; Pisake Lumbiganon; Mario R Festin; Jacqueline J Ho; Hakimi Mohammad; Steve J McDonald; Sally Green; Caroline A Crowther Journal: BMC Med Res Methodol Date: 2007-09-24 Impact factor: 4.615