Literature DB >> 11335133

Expression of Irx6 during mouse morphogenesis.

J Mummenhoff1, A C Houweling, T Peters, V M Christoffels, U Rüther.   

Abstract

Iroquois (Irx) proteins comprise a family of homeodomain-containing transcription factors involved in patterning and regionalization of embryonic tissues in both vertebrates and invertebrates. The six murine Irx genes are organized in two clusters, each consisting of three genes. Irx1, Irx2 and Irx4 belong to the IrxA cluster on chromosome 13, whereas Irx3, Irx5 and Irx6, comprising the IrxB cluster, are located on chromosome 8 (Peters et al., Genome Res. 10 (2000) 1453). Developmental expression patterns have so far only been reported for five Irx genes. Here, we investigated the expression pattern of Irx6 during mouse morphogenesis and early organogenesis. The pattern was found to be much more restricted compared to the other five Irx genes, and its level of expression was much lower.

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Year:  2001        PMID： 11335133     DOI： 10.1016/s0925-4773(01)00353-7

Source DB:  PubMed          Journal:  Mech Dev        ISSN： 0925-4773            Impact factor:   1.882


  10 in total

1.  Iroquois homeobox gene 3 establishes fast conduction in the cardiac His-Purkinje network.

Authors:  Shan-Shan Zhang; Kyoung-Han Kim; Anna Rosen; James W Smyth; Rui Sakuma; Paul Delgado-Olguín; Mark Davis; Neil C Chi; Vijitha Puviindran; Nathalie Gaborit; Tatyana Sukonnik; John N Wylie; Koroboshka Brand-Arzamendi; Gerrie P Farman; Jieun Kim; Robert A Rose; Phillip A Marsden; Yonghong Zhu; Yu-Qing Zhou; Lucile Miquerol; R Mark Henkelman; Didier Y R Stainier; Robin M Shaw; Chi-chung Hui; Benoit G Bruneau; Peter H Backx
Journal:  Proc Natl Acad Sci U S A       Date:  2011-08-08       Impact factor: 11.205

2.  Cooperative and antagonistic roles for Irx3 and Irx5 in cardiac morphogenesis and postnatal physiology.

Authors:  Nathalie Gaborit; Rui Sakuma; John N Wylie; Kyoung-Han Kim; Shan-Shan Zhang; Chi-Chung Hui; Benoit G Bruneau
Journal:  Development       Date:  2012-09-19       Impact factor: 6.868

3.  Comparison of Iroquois gene expression in limbs/fins of vertebrate embryos.

Authors:  Laura A McDonald; Dianne Gerrelli; Yvonne Fok; Laurence D Hurst; Cheryll Tickle
Journal:  J Anat       Date:  2010-04-14       Impact factor: 2.610

4.  The homeodomain transcription factor Irx5 establishes the mouse cardiac ventricular repolarization gradient.

Authors:  Danny L Costantini; Eric P Arruda; Pooja Agarwal; Kyoung-Han Kim; Yonghong Zhu; Wei Zhu; Melanie Lebel; Chi Wa Cheng; Chong Y Park; Stephanie A Pierce; Alejandra Guerchicoff; Guido D Pollevick; Toby Y Chan; M Golam Kabir; Shuk Han Cheng; Mansoor Husain; Charles Antzelevitch; Deepak Srivastava; Gil J Gross; Chi-chung Hui; Peter H Backx; Benoit G Bruneau
Journal:  Cell       Date:  2005-10-21       Impact factor: 41.582

5.  The Iroquois homeobox gene Irx2 is not essential for normal development of the heart and midbrain-hindbrain boundary in mice.

Authors:  Mélanie Lebel; Pooja Agarwal; Chi Wa Cheng; M Golam Kabir; Toby Y Chan; Vijitha Thanabalasingham; Xiaoyun Zhang; Dana R Cohen; Mansoor Husain; Shuk Han Cheng; Benoit G Bruneau; Chi-Chung Hui
Journal:  Mol Cell Biol       Date:  2003-11       Impact factor: 4.272

Review 6.  Genetic control of retinal ganglion cell genesis.

Authors:  Jianyi Lyu; Xiuqian Mu
Journal:  Cell Mol Life Sci       Date:  2021-03-29       Impact factor: 9.261

7.  A duplication on chromosome 16q12 affecting the IRXB gene cluster is associated with autosomal dominant cone dystrophy with early tritanopic color vision defect.

Authors:  Susanne Kohl; Pablo Llavona; Alexandra Sauer; Peggy Reuter; Nicole Weisschuh; Melanie Kempf; Florian Alexander Dehmelt; Aristides B Arrenberg; Ieva Sliesoraityte; Eberhart Zrenner; Mary J van Schooneveld; Günther Rudolph; Laura Kühlewein; Bernd Wissinger
Journal:  Hum Mol Genet       Date:  2021-06-17       Impact factor: 6.150

8.  Spatiotemporal single-cell RNA sequencing of developing chicken hearts identifies interplay between cellular differentiation and morphogenesis.

Authors:  Madhav Mantri; Gaetano J Scuderi; Roozbeh Abedini-Nassab; Michael F Z Wang; David McKellar; Hao Shi; Benjamin Grodner; Jonathan T Butcher; Iwijn De Vlaminck
Journal:  Nat Commun       Date:  2021-03-19       Impact factor: 14.919

9.  Epigenetic clustering of lung adenocarcinomas based on DNA methylation profiles in adjacent lung tissue: Its correlation with smoking history and chronic obstructive pulmonary disease.

Authors:  Takashi Sato; Eri Arai; Takashi Kohno; Yoriko Takahashi; Sayaka Miyata; Koji Tsuta; Shun-ichi Watanabe; Kenzo Soejima; Tomoko Betsuyaku; Yae Kanai
Journal:  Int J Cancer       Date:  2014-07-15       Impact factor: 7.396

Review 10.  Iroquois Homeodomain transcription factors in ventricular conduction system and arrhythmia.

Authors:  Wenyu Hu; Yanguo Xin; Lin Zhang; Jian Hu; Yingxian Sun; Yinan Zhao
Journal:  Int J Med Sci       Date:  2018-05-22       Impact factor: 3.738
  10 in total

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