Literature DB >> 11334974

A new multiplex PCR strategy for the simultaneous determination of four genetic polymorphisms affecting HIV-1 disease progression.

T B Kristiansen1, T B Knudsen, S Ohlendorff, J Eugen-Olsen.   

Abstract

The CCR5 Delta32, CCR2 64I, SDF1 3'A, and CCR5 promoter 59029 polymorphisms have been suggested to influence HIV-1 disease progression. Furthermore, the CCR5 Delta32 and the CCR2 64I polymorphisms have been associated with various other diseases. The purpose of the present study was to develop a multiplex assay for the simultaneous determination of these four polymorphisms. Results obtained with the multiplex assay were compared to results obtained by conventional RFLP-PCR and no differences were observed. The multiplex assay offers a quick tool for the determination of the CCR5 Delta32, CCR2 64I, SDF1 3'A, and CCR5 promoter 59029 A/G polymorphisms.

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Year:  2001        PMID： 11334974     DOI： 10.1016/s0022-1759(01)00349-0

Source DB:  PubMed          Journal:  J Immunol Methods        ISSN： 0022-1759            Impact factor:   2.303


  15 in total

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4.  Case of yellow fever vaccine--associated viscerotropic disease with prolonged viremia, robust adaptive immune responses, and polymorphisms in CCR5 and RANTES genes.

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7.  Distribution of CCR5-Delta32, CCR5 promoter 59029 A/G, CCR2-64I and SDF1-3'A genetic polymorphisms in HIV-1 infected and uninfected patients in the west region of Cameroon.

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9.  Sequence variants of chemokine receptor genes and susceptibility to HIV-1 infection.

Authors:  M Parczewski; M Leszczyszyn-Pynka; M Kaczmarczyk; G Adler; A Binczak-Kuleta; B Loniewska; A Boron-Kaczmarska; A Ciechanowicz
Journal:  J Appl Genet       Date:  2009       Impact factor: 2.653

10.  CCR5Delta32 genotypes in a German HIV-1 seroconverter cohort and report of HIV-1 infection in a CCR5Delta32 homozygous individual.

Authors:  Djin-Ye Oh; Heiko Jessen; Claudia Kücherer; Konrad Neumann; Nari Oh; Gabriele Poggensee; Barbara Bartmeyer; Arne Jessen; Axel Pruss; Ralf R Schumann; Osamah Hamouda
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