Literature DB >> 11334879

12-Hydroxyeicosatetraenoic acid potentiates angiotensin II-induced pressor response in rats.

S Takai1, D Jin, K Kirimura, Y Fujimoto, M Miyazaki.   

Abstract

We studied whether 12-hydroxyeicosatetraenoic acid (HETE) affected the angiotensin II-induced pressor response in rats. After intravenous administration of 1 and 3 microg/kg 12-HETE, the angiotensin II-induced pressor response was not potentiated. However, 10, 20 and 30 min after the administration of 10 microg/kg 12-HETE, the angiotensin II-induced pressor responses were increased by 7.5, 6.8 and 4.8 mm Hg, respectively. The significant pressor response was observed at 10 and 20 min after the administration. In this study, we clearly demonstrated that 12-HETE potentiated the angiotensin II-induced pressor response.

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Year:  2001        PMID： 11334879     DOI： 10.1016/s0014-2999(01)00935-9

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  2 in total

1.  Macrophage 12(S)-HETE Enhances Angiotensin II-Induced Contraction by a BLT2 (Leukotriene B4 Type-2 Receptor) and TP (Thromboxane Receptor)-Mediated Mechanism in Murine Arteries.

Authors:  Tamas Kriska; Anja Herrnreiter; Sandra L Pfister; Adeniyi Adebesin; John R Falck; William B Campbell
Journal:  Hypertension       Date:  2021-11-17       Impact factor: 10.190

2.  Deactivation of 12(S)-HETE through (ω-1)-hydroxylation and β-oxidation in alternatively activated macrophages.

Authors:  Tamas Kriska; Michael J Thomas; John R Falck; William B Campbell
Journal:  J Lipid Res       Date:  2018-02-22       Impact factor: 5.922
  2 in total

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