| Literature DB >> 11333931 |
S C Frey1, E A Hoover, J I Mullins.
Abstract
The process of feline immunodeficiency virus (FIV) cell entry was examined using assays for virus replication intermediates. FIV subtype B was found to utilize the chemokine receptor CXCR4, but not CCR5, as a cellular receptor. Zidovudine blocked formation of late viral replication products most effectively, including circular DNA genome intermediates. Our findings extend the role of CXCR4 as a primary receptor for CD4-independent cell entry by FIV.Entities:
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Year: 2001 PMID: 11333931 PMCID: PMC114955 DOI: 10.1128/JVI.75.11.5433-5440.2001
Source DB: PubMed Journal: J Virol ISSN: 0022-538X Impact factor: 5.103