Literature DB >> 11333439

Advanced glycation end products: a highly complex set of biologically relevant compounds detected by mass spectrometry.

A Lapolla1, D Fedele, L Martano, N C Arico', M Garbeglio, P Traldi, R Seraglia, D Favretto.   

Abstract

Structural information on 'AGE-peptides,' a class of substances belonging to advanced glycation end products (AGE) and originating by proteolysis of glycated proteins, was gained through various analytical approaches on the mixture produced by proteinase K digestion of in vitro glycated bovine serum albumin. Both matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) and high-performance liquid chromatography/electrospray ionization mass spectrometry (HPLC/ESI-MS) were employed, and the results were compared with those from conventional spectroscopic methods (UV, fluorescence, gel permeation). The data acquired by the various techniques all depict the digestion mixtures as highly complex, with components exhibiting molecular mass in the range 300-3500 Da. In the analysis of HPLC/ESI-MS data, identification of AGE-peptides was facilitated by 3D mapping. Structural information was gained by means of multiple mass spectrometric experiments. Copyright 2001 John Wiley & Sons, Ltd.

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Year:  2001        PMID： 11333439     DOI： 10.1002/jms.137

Source DB:  PubMed          Journal:  J Mass Spectrom        ISSN： 1076-5174            Impact factor:   1.982


  8 in total

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2.  Nanoscale changes in collagen are reflected in physical and mechanical properties of bone at the microscale in diabetic rats.

Authors:  Max A Hammond; Maxime A Gallant; David B Burr; Joseph M Wallace
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3.  Mass spectrometric characterization of glycated beta-lactoglobulin peptides derived from galacto-oligosaccharides surviving the in vitro gastrointestinal digestion.

Authors:  F Javier Moreno; Jesús Eduardo Quintanilla-López; Rosa Lebrón-Aguilar; Agustín Olano; María Luz Sanz
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4.  Involvement of Maillard reactions in Alzheimer disease.

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Journal:  Neurotox Res       Date:  2002-05       Impact factor: 3.911

5.  Proteome wide reduction in AGE modification in streptozotocin induced diabetic mice by hydralazine mediated transglycation.

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Journal:  Sci Rep       Date:  2013-10-15       Impact factor: 4.379

Review 6.  Role of advanced glycation end products in cellular signaling.

Authors:  Christiane Ott; Kathleen Jacobs; Elisa Haucke; Anne Navarrete Santos; Tilman Grune; Andreas Simm
Journal:  Redox Biol       Date:  2014-01-09       Impact factor: 11.799

7.  GlyStruct: glycation prediction using structural properties of amino acid residues.

Authors:  Hamendra Manhar Reddy; Alok Sharma; Abdollah Dehzangi; Daichi Shigemizu; Abel Avitesh Chandra; Tatushiko Tsunoda
Journal:  BMC Bioinformatics       Date:  2019-02-04       Impact factor: 3.169

8.  Glypre: In Silico Prediction of Protein Glycation Sites by Fusing Multiple Features and Support Vector Machine.

Authors:  Xiaowei Zhao; Xiaosa Zhao; Lingling Bao; Yonggang Zhang; Jiangyan Dai; Minghao Yin
Journal:  Molecules       Date:  2017-11-03       Impact factor: 4.411
  8 in total

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