Literature DB >> 11332656

The origin and regulation of autopathogenic T cells.

A C Anderson1, L B Nicholson, V K Kuchroo.   

Abstract

A clear understanding of the events surrounding the selection of autoreactive T cells in the thymus and their regulation in the periphery has eluded immunologists for years. However, recent work examining the expression of tissue-specific antigens in the thymus and the biochemistry of disease associated MHC alleles has provided important clues into the generation of the autoreactive T cell repertoire in the thymus. In addition, recent studies focusing on the role of immunoregulatory cytokines and cross-reactive peptide ligands has provided information regarding both the regulation and activation of autoreactive cells in the periphery. An improved understanding of the selection and regulation of autoreactive T cells will undoubtedly aid in the development of strategies for treating autoimmune disease.

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Mesh：

Year:  2001        PMID： 11332656     DOI： 10.1023/a:1011027020890

Source DB:  PubMed          Journal:  J Clin Immunol        ISSN： 0271-9142            Impact factor:   8.317


  43 in total

Review 1.  A very high level of crossreactivity is an essential feature of the T-cell receptor.

Authors:  D Mason
Journal:  Immunol Today       Date:  1998-09

2.  Pathologic role and temporal appearance of newly emerging autoepitopes in relapsing experimental autoimmune encephalomyelitis.

Authors:  C L Vanderlugt; K L Neville; K M Nikcevich; T N Eagar; J A Bluestone; S D Miller
Journal:  J Immunol       Date:  2000-01-15       Impact factor: 5.422

3.  Prevention and treatment of relapsing autoimmune encephalomyelitis with myelin peptide-coupled splenocytes.

Authors:  A A Vandenbark; M Vainiene; K Ariail; S D Miller; H Offner
Journal:  J Neurosci Res       Date:  1996-08-15       Impact factor: 4.164

4.  Fulminant spontaneous autoimmunity of the central nervous system in mice transgenic for the myelin proteolipid protein-specific T cell receptor.

Authors:  H Waldner; M J Whitters; R A Sobel; M Collins; V K Kuchroo
Journal:  Proc Natl Acad Sci U S A       Date:  2000-03-28       Impact factor: 11.205

5.  Myelin protein expression is increased in lymph nodes of mice with relapsing experimental autoimmune encephalomyelitis.

Authors:  A J MacKenzie-Graham; T M Pribyl; S Kim; V R Porter; A T Campagnoni; R R Voskuhl
Journal:  J Immunol       Date:  1997-11-01       Impact factor: 5.422

6.  Evidence for a differential avidity model of T cell selection in the thymus.

Authors:  P G Ashton-Rickardt; A Bandeira; J R Delaney; L Van Kaer; H P Pircher; R M Zinkernagel; S Tonegawa
Journal:  Cell       Date:  1994-02-25       Impact factor: 41.582

7.  Structural basis of peptide binding and presentation by the type I diabetes-associated MHC class II molecule of NOD mice.

Authors:  R R Latek; A Suri; S J Petzold; C A Nelson; O Kanagawa; E R Unanue; D H Fremont
Journal:  Immunity       Date:  2000-06       Impact factor: 31.745

8.  T helper cell subsets in insulin-dependent diabetes.

Authors:  J D Katz; C Benoist; D Mathis
Journal:  Science       Date:  1995-05-26       Impact factor: 47.728

9.  High frequency of autoreactive myelin proteolipid protein-specific T cells in the periphery of naive mice: mechanisms of selection of the self-reactive repertoire.

Authors:  A C Anderson; L B Nicholson; K L Legge; V Turchin; H Zaghouani; V K Kuchroo
Journal:  J Exp Med       Date:  2000-03-06       Impact factor: 14.307

10.  Functional evidence for epitope spreading in the relapsing pathology of experimental autoimmune encephalomyelitis.

Authors:  B L McRae; C L Vanderlugt; M C Dal Canto; S D Miller
Journal:  J Exp Med       Date:  1995-07-01       Impact factor: 14.307
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