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Literature DB >> 11331921

Olfactory ensheathing cells - another miracle cure for spinal cord injury?

Abstract

Several recent publications describe remarkably promising effects of transplanting olfactory ensheathing cells as a potential future method to repair human spinal cord injuries. But why were cells from the nose transplanted into the spinal cord? What are olfactory ensheathing cells, and how might they produce these beneficial effects? And more generally, what do we mean by spinal cord injury? To what extent can we compare repair in an animal to repair in a human?

Entities: Disease Species

Mesh：

Year: 2001 PMID： 11331921 DOI： 10.1038/35072576

Source DB: PubMed Journal: Nat Rev Neurosci ISSN： 1471-003X Impact factor: 34.870

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Cited

51 in total

1. LacZ-expressing olfactory ensheathing cells do not associate with myelinated axons after implantation into the compressed spinal cord.

Authors: J G Boyd; J Lee; V Skihar; R Doucette; M D Kawaja
Journal: Proc Natl Acad Sci U S A Date: 2004-02-05 Impact factor: 11.205

2. Transplantation of olfactory ensheathing cells into spinal cord lesions restores breathing and climbing.

Authors: Ying Li; Patrick Decherchi; Geoffrey Raisman
Journal: J Neurosci Date: 2003-02-01 Impact factor: 6.167

3. Transplantation of olfactory mucosa minimizes axonal branching and promotes the recovery of vibrissae motor performance after facial nerve repair in rats.

Authors: Orlando Guntinas-Lichius; Konstantin Wewetzer; Toma L Tomov; Natalie Azzolin; Shohreh Kazemi; Michael Streppel; Wolfrum F Neiss; Doychin N Angelov
Journal: J Neurosci Date: 2002-08-15 Impact factor: 6.167

Review 4. Central nervous system lesions that can and those that cannot be repaired with the help of olfactory bulb ensheathing cell transplants.

Authors: Manuel Nieto-Sampedro
Journal: Neurochem Res Date: 2003-11 Impact factor: 3.996

Review 5. The dark side of neuroplasticity.

Authors: Arthur Brown; Lynne C Weaver
Journal: Exp Neurol Date: 2011-11-12 Impact factor: 5.330

10. Neurotrophin modulation of voltage-gated potassium channels in rat through TrkB receptors is time and sensory experience dependent.

Authors: K Tucker; D A Fadool
Journal: J Physiol Date: 2002-07-15 Impact factor: 5.182

Olfactory ensheathing cells - another miracle cure for spinal cord injury?

1. LacZ-expressing olfactory ensheathing cells do not associate with myelinated axons after implantation into the compressed spinal cord.

2. Transplantation of olfactory ensheathing cells into spinal cord lesions restores breathing and climbing.

3. Transplantation of olfactory mucosa minimizes axonal branching and promotes the recovery of vibrissae motor performance after facial nerve repair in rats.

Review 4. Central nervous system lesions that can and those that cannot be repaired with the help of olfactory bulb ensheathing cell transplants.

Review 5. The dark side of neuroplasticity.

6. Denervation affects regenerative responses in MRL/MpJ and repair in C57BL/6 ear wounds.

Review 7. Failed central nervous system regeneration: a downside of immune privilege?

Review 8. Molecular targets in spinal cord injury.

Review 9. Genetic manipulation of neural stem cells for transplantation into the injured spinal cord.

10. Neurotrophin modulation of voltage-gated potassium channels in rat through TrkB receptors is time and sensory experience dependent.