Literature DB >> 11331920

Cell therapy in Parkinson's disease - stop or go?

S B Dunnett, A Björklund, O Lindvall.   

Abstract

The results of the first double-blind placebo-controlled trial using grafts of embryonic tissue to treat Parkinson's disease have aroused widespread interest and debate about the future of cell replacement therapies. What are the key issues that need to be resolved and the directions in which this technology is likely to develop?

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Mesh：

Year:  2001        PMID： 11331920     DOI： 10.1038/35072572

Source DB:  PubMed          Journal:  Nat Rev Neurosci        ISSN： 1471-003X            Impact factor:   34.870


  47 in total

Review 1.  Health-related quality of life and healthcare utilisation in patients with Parkinson's disease: impact of motor fluctuations and dyskinesias.

Authors:  R C Dodel; K Berger; W H Oertel
Journal:  Pharmacoeconomics       Date:  2001       Impact factor: 4.981

2.  Unilateral transplantation of human primary fetal tissue in four patients with Huntington's disease: NEST-UK safety report ISRCTN no 36485475.

Authors:  A E Rosser; R A Barker; T Harrower; C Watts; M Farrington; A K Ho; R M Burnstein; D K Menon; J H Gillard; J Pickard; S B Dunnett
Journal:  J Neurol Neurosurg Psychiatry       Date:  2002-12       Impact factor: 10.154

3.  Pitx3 is required for development of substantia nigra dopaminergic neurons.

Authors:  Irene Nunes; Lucy T Tovmasian; Robert M Silva; Robert E Burke; Stephen P Goff
Journal:  Proc Natl Acad Sci U S A       Date:  2003-03-24       Impact factor: 11.205

Review 4.  Neural transplantation in patients with Huntington's disease.

Authors:  Anne E Rosser; Stephen B Dunnett
Journal:  CNS Drugs       Date:  2003       Impact factor: 5.749

5.  Effects of GDF5 overexpression on embryonic rat dopaminergic neurones in vitro and in vivo.

Authors:  David B O'Sullivan; Patrick T Harrison; Aideen M Sullivan
Journal:  J Neural Transm (Vienna)       Date:  2010-03-27       Impact factor: 3.575

6.  Morphological characterization of GFP stably transfected adult mesenchymal bone marrow stem cells.

Authors:  Stefania Raimondo; Claudia Penna; Pasquale Pagliaro; Stefano Geuna
Journal:  J Anat       Date:  2006-01       Impact factor: 2.610

Review 7.  Strengths and limitations of the neurosphere culture system.

Authors:  Josephine B Jensen; Malin Parmar
Journal:  Mol Neurobiol       Date:  2006-12       Impact factor: 5.590

Review 8.  Genetic modification of human embryonic stem cells.

Authors:  Xiaofeng Xia; Su-Chun Zhang
Journal:  Biotechnol Genet Eng Rev       Date:  2007

9.  Large animal models are critical for rationally advancing regenerative therapies.

Authors:  Dustin R Wakeman; Andrew M Crain; Evan Y Snyder
Journal:  Regen Med       Date:  2006-07       Impact factor: 3.806

Review 10.  Cellular transplantation strategies for spinal cord injury and translational neurobiology.

Authors:  Paul J Reier
Journal:  NeuroRx       Date:  2004-10
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