Literature DB >> 11331912

A weak signal for strong responses: interferon-alpha/beta revisited.

T Taniguchi1, A Takaoka.   

Abstract

Biological systems have acquired adaptability and robustness against rapid environmental changes. A typical example is the immune system, which eradicates invading pathogens such as viruses. Interferons alpha and beta, which are produced in response to viral infection, are essential components of this system but are also produced at low levels in the absence of infection. What is the purpose of the constitutive weak interferon-alpha/beta signal?

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Year:  2001        PMID： 11331912     DOI： 10.1038/35073080

Source DB:  PubMed          Journal:  Nat Rev Mol Cell Biol        ISSN： 1471-0072            Impact factor:   94.444


  190 in total

Review 1.  IFNs and STATs in innate immunity to microorganisms.

Authors:  Thomas Decker; Silvia Stockinger; Marina Karaghiosoff; Mathias Müller; Pavel Kovarik
Journal:  J Clin Invest       Date:  2002-05       Impact factor: 14.808

2.  Contribution of a TANK-binding kinase 1-interferon (IFN) regulatory factor 7 pathway to IFN-γ-induced gene expression.

Authors:  Matthias Farlik; Birgit Rapp; Isabelle Marie; David E Levy; Amanda M Jamieson; Thomas Decker
Journal:  Mol Cell Biol       Date:  2012-01-17       Impact factor: 4.272

Review 3.  Type I IFN-mediated regulation of IL-1 production in inflammatory disorders.

Authors:  Kristina Ludigs; Valeriy Parfenov; Renaud A Du Pasquier; Greta Guarda
Journal:  Cell Mol Life Sci       Date:  2012-04-24       Impact factor: 9.261

4.  Distinct roles for the NF-kappa B RelA subunit during antiviral innate immune responses.

Authors:  Suresh H Basagoudanavar; Roshan J Thapa; Shoko Nogusa; Junmei Wang; Amer A Beg; Siddharth Balachandran
Journal:  J Virol       Date:  2011-01-05       Impact factor: 5.103

5.  Enhanced anti-melanoma efficacy of interferon alfa-2b via inhibition of Shp2.

Authors:  Hla Win-Piazza; Valentina E Schneeberger; Liwei Chen; Daniele Pernazza; Harshani R Lawrence; Said M Sebti; Nicholas J Lawrence; Jie Wu
Journal:  Cancer Lett       Date:  2012-02-01       Impact factor: 8.679

6.  Activation of Oas1a gene expression by type I IFN requires both STAT1 and STAT2 while only STAT2 is required for Oas1b activation.

Authors:  Joanna A Pulit-Penaloza; Svetlana V Scherbik; Margo A Brinton
Journal:  Virology       Date:  2012-02-03       Impact factor: 3.616

7.  Cytokine Activation by Antibody Fragments Targeted to Cytokine-Receptor Signaling Complexes.

Authors:  Srilalitha Kuruganti; Shane Miersch; Ashlesha Deshpande; Jeffrey A Speir; Bethany D Harris; Jill M Schriewer; R Mark L Buller; Sachdev S Sidhu; Mark R Walter
Journal:  J Biol Chem       Date:  2015-11-06       Impact factor: 5.157

Review 8.  Innate antiviral immune signaling, viral evasion and modulation by HIV-1.

Authors:  Arjun Rustagi; Michael Gale
Journal:  J Mol Biol       Date:  2013-12-08       Impact factor: 5.469

9.  Bioluminescence imaging reveals systemic dissemination of herpes simplex virus type 1 in the absence of interferon receptors.

Authors:  Gary D Luker; Julie L Prior; Jiling Song; Christina M Pica; David A Leib
Journal:  J Virol       Date:  2003-10       Impact factor: 5.103

10.  Raf inhibitor stabilizes receptor for the type I interferon but inhibits its anti-proliferative effects in human malignant melanoma cells.

Authors:  K G Suresh Kumar; Jianghuai Liu; Ying Li; Duonan Yu; Andrei Thomas-Tikhonenko; Meenhard Herlyn; Serge Y Fuchs
Journal:  Cancer Biol Ther       Date:  2007-06-13       Impact factor: 4.742
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