Literature DB >> 11331246

Control of p53 ubiquitination and nuclear export by MDM2 and ARF.

Y Zhang1, Y Xiong.   

Abstract

p53 and ARF-INK4a are the two most frequently altered loci in human tumors. The activity of p53 protein is inhibited during normal cell growth by the proto-oncoprotein MDM2 through either repression of p53-mediated transcription in the nucleus or proteasomal degradation of p53 protein in the cytoplasm. Responding to oncogenic signal-activated cell hyperproliferation, ARF-mediated antagonism of MDM2 inhibition results in p53 becoming active and its protein levels rising. The biochemical mechanisms of ubiquitination and nuclear export that underlie the functions of ARF and MDM2 in p53 control continue to emerge.

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Year:  2001        PMID： 11331246

Source DB:  PubMed          Journal:  Cell Growth Differ        ISSN： 1044-9523


  64 in total

1.  Degradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complex.

Authors:  E Querido; P Blanchette; Q Yan; T Kamura; M Morrison; D Boivin; W G Kaelin; R C Conaway; J W Conaway; P E Branton
Journal:  Genes Dev       Date:  2001-12-01       Impact factor: 11.361

2.  DNA damage induces MDMX nuclear translocation by p53-dependent and -independent mechanisms.

Authors:  Changgong Li; Lihong Chen; Jiandong Chen
Journal:  Mol Cell Biol       Date:  2002-11       Impact factor: 4.272

3.  Localization of sequences in a protein (ORF2) encoded by the latency-related gene of bovine herpesvirus 1 that inhibits apoptosis and interferes with Notch1-mediated trans-activation of the bICP0 promoter.

Authors:  Devis Sinani; Clinton Jones
Journal:  J Virol       Date:  2011-09-21       Impact factor: 5.103

4.  Differential regulation of E2F1, DP1, and the E2F1/DP1 complex by ARF.

Authors:  Abhishek Datta; Alo Nag; Pradip Raychaudhuri
Journal:  Mol Cell Biol       Date:  2002-12       Impact factor: 4.272

5.  Alternative reading frame protein (ARF)-independent function of CARF (collaborator of ARF) involves its interactions with p53: evidence for a novel p53-activation pathway and its negative feedback control.

Authors:  Md Kamrul Hasan; Tomoko Yaguchi; Yasumasu Minoda; Takashi Hirano; Kazunari Taira; Renu Wadhwa; Sunil C Kaul
Journal:  Biochem J       Date:  2004-06-15       Impact factor: 3.857

6.  Perturbation of 60 S ribosomal biogenesis results in ribosomal protein L5- and L11-dependent p53 activation.

Authors:  Xiao-Xin Sun; Yue-Gang Wang; Dimitris P Xirodimas; Mu-Shui Dai
Journal:  J Biol Chem       Date:  2010-06-16       Impact factor: 5.157

7.  MDM2 recruitment of lysine methyltransferases regulates p53 transcriptional output.

Authors:  Lihong Chen; Zhenyu Li; Aleksandra K Zwolinska; Matthew A Smith; Brittany Cross; John Koomen; Zhi-Min Yuan; Thomas Jenuwein; Jean-Christophe Marine; Kenneth L Wright; Jiandong Chen
Journal:  EMBO J       Date:  2010-06-29       Impact factor: 11.598

8.  MDMX regulation of p53 response to ribosomal stress.

Authors:  Daniele M Gilkes; Lihong Chen; Jiandong Chen
Journal:  EMBO J       Date:  2006-11-16       Impact factor: 11.598

9.  Cancer-associated mutations in the MDM2 zinc finger domain disrupt ribosomal protein interaction and attenuate MDM2-induced p53 degradation.

Authors:  Mikael S Lindström; Aiwen Jin; Chad Deisenroth; Gabrielle White Wolf; Yanping Zhang
Journal:  Mol Cell Biol       Date:  2006-11-20       Impact factor: 4.272

Review 10.  The moving parts of the nucleolus.

Authors:  M O J Olson; Miroslav Dundr
Journal:  Histochem Cell Biol       Date:  2005-03-02       Impact factor: 4.304
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