Literature DB >> 11330807

Isolation and structural characterization of polymyxin B components.

J A Orwa1, C Govaerts, R Busson, E Roets, A Van Schepdael, J Hoogmartens.   

Abstract

Polymyxin B is a peptide antibiotic complex present as sulphate. The components were separated preparatively on a poly(styrene-divinylbenzene) (PLRP-S), 1000 A, 8 microm, 250 x 12.5 mm I.D. stationary phase maintained at 60 degrees C and using 215 nm detection. Elution was carried out with acetonitrile-sodium sulphate solution (0.7%, m/v; pH adjusted to 2.5 with trifluoroacetic acid)-water (18:50:32, v/v) at a flow-rate of 4.0 ml/min. Seven polymyxin B components were isolated and characterized using 1H and 13C NMR. The molecular masses were confirmed by mass spectrometry. The structures of two components were determined for the first time. Polymyxins B5 and B6 were identified as having the same composition as polymyxin B1 except that the fatty acid moiety was nonanoic acid and 3-hydroxy-6-methyloctanoic acid, respectively.

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Year:  2001        PMID： 11330807     DOI： 10.1016/s0021-9673(01)00585-4

Source DB:  PubMed          Journal:  J Chromatogr A        ISSN： 0021-9673            Impact factor:   4.759


  27 in total

Review 1.  Structure--activity relationships of polymyxin antibiotics.

Authors:  Tony Velkov; Philip E Thompson; Roger L Nation; Jian Li
Journal:  J Med Chem       Date:  2010-03-11       Impact factor: 7.446

2.  In vitro potency of various polymyxin B components.

Authors:  Vincent H Tam; Henry Cao; Kimberly R Ledesma; Ming Hu
Journal:  Antimicrob Agents Chemother       Date:  2011-06-27       Impact factor: 5.191

Review 3.  Development of new polymyxin derivatives for multi-drug resistant Gram-negative infections.

Authors:  Pamela Brown; Michael J Dawson
Journal:  J Antibiot (Tokyo)       Date:  2017-01-11       Impact factor: 2.649

4.  Comparative Pharmacokinetic Profiling of Different Polymyxin B Components.

Authors:  Pooja Manchandani; Yanina Dubrovskaya; Song Gao; Vincent H Tam
Journal:  Antimicrob Agents Chemother       Date:  2016-10-21       Impact factor: 5.191

5.  Pharmacokinetics and efficacy of liposomal polymyxin B in a murine pneumonia model.

Authors:  Jie He; Kamilia Abdelraouf; Kimberly R Ledesma; Diana S-L Chow; Vincent H Tam
Journal:  Int J Antimicrob Agents       Date:  2013-08-22       Impact factor: 5.283

6.  Design, synthesis, and evaluation of a new fluorescent probe for measuring polymyxin-lipopolysaccharide binding interactions.

Authors:  Rachel L Soon; Tony Velkov; Francis Chiu; Philip E Thompson; Rashmi Kancharla; Kade Roberts; Ian Larson; Roger L Nation; Jian Li
Journal:  Anal Biochem       Date:  2010-11-02       Impact factor: 3.365

7.  Liquid crystalline bacterial outer membranes are critical for antibiotic susceptibility.

Authors:  Nicolò Paracini; Luke A Clifton; Maximilian W A Skoda; Jeremy H Lakey
Journal:  Proc Natl Acad Sci U S A       Date:  2018-07-23       Impact factor: 11.205

8.  Pharmacokinetics and renal disposition of polymyxin B in an animal model.

Authors:  Kamilia Abdelraouf; Jie He; Kimberly R Ledesma; Ming Hu; Vincent H Tam
Journal:  Antimicrob Agents Chemother       Date:  2012-08-20       Impact factor: 5.191

Review 9.  Rescuing the Last-Line Polymyxins: Achievements and Challenges.

Authors:  Sue C Nang; Mohammad A K Azad; Tony Velkov; Qi Tony Zhou; Jian Li
Journal:  Pharmacol Rev       Date:  2021-04       Impact factor: 25.468

10.  Antimicrobial Activity and Toxicity of the Major Lipopeptide Components of Polymyxin B and Colistin: Last-line Antibiotics against Multidrug-Resistant Gram-negative Bacteria.

Authors:  Kade D Roberts; Mohammad A K Azad; Jiping Wang; Andrew S Horne; Philip E Thompson; Roger L Nation; Tony Velkov; Jian Li
Journal:  ACS Infect Dis       Date:  2015-09-04       Impact factor: 5.084
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