Literature DB >> 11330435

Trovafloxacin hepatotoxicity.

D A Lazarczyk1, N S Goldstein, S C Gordon.   

Abstract

A 19-year-old woman was treated for recurrent sinusitis with oral trovafloxacin and developed acute hepatitis and peripheral eosinophilia, with hepatosplenomegaly and ascites. Laparoscopic liver biopsy showed extensive centrilobular hepatocyte necrosis, likely causing venooclusive disease-like signs and symptoms. Clinical and laboratory abnormalities resolved completely after prolonged treatment with steroids. The temporal relationship between trovafloxacin and the onset of hepatitis favors this drug as a culprit.

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Year:  2001        PMID： 11330435     DOI： 10.1023/a:1010741510046

Source DB:  PubMed          Journal:  Dig Dis Sci        ISSN： 0163-2116            Impact factor:   3.199


  2 in total

1.  From the Food and Drug Administration.

Authors:  S L Nightingale
Journal:  JAMA       Date:  1999-07-07       Impact factor: 56.272

2.  Acute eosinophilic hepatitis from trovafloxacin.

Authors:  H J Chen; K J Bloch; J A Maclean
Journal:  N Engl J Med       Date:  2000-02-03       Impact factor: 91.245
  2 in total
  6 in total

Review 1.  Idiosyncratic drug-induced liver injury and the role of inflammatory stress with an emphasis on an animal model of trovafloxacin hepatotoxicity.

Authors:  Patrick J Shaw; Patricia E Ganey; Robert A Roth
Journal:  Toxicol Sci       Date:  2010-06-10       Impact factor: 4.849

2.  Clinical and histopathologic features of fluoroquinolone-induced liver injury.

Authors:  Eric S Orman; Hari S Conjeevaram; Raj Vuppalanchi; James W Freston; James Rochon; David E Kleiner; Paul H Hayashi
Journal:  Clin Gastroenterol Hepatol       Date:  2011-02-26       Impact factor: 11.382

3.  In Vitro Activity of AZD0914, a Novel Bacterial DNA Gyrase/Topoisomerase IV Inhibitor, against Clinically Relevant Gram-Positive and Fastidious Gram-Negative Pathogens.

Authors:  Douglas J Biedenbach; Michael D Huband; Meredith Hackel; Boudewijn L M de Jonge; Daniel F Sahm; Patricia A Bradford
Journal:  Antimicrob Agents Chemother       Date:  2015-07-20       Impact factor: 5.191

4.  Trovafloxacin enhances TNF-induced inflammatory stress and cell death signaling and reduces TNF clearance in a murine model of idiosyncratic hepatotoxicity.

Authors:  Patrick J Shaw; Kevin M Beggs; Erica M Sparkenbaugh; Christine M Dugan; Patricia E Ganey; Robert A Roth
Journal:  Toxicol Sci       Date:  2009-07-28       Impact factor: 4.849

5.  Identification and characterization of potential therapeutic candidates in emerging human pathogen Mycobacterium abscessus: a novel hierarchical in silico approach.

Authors:  Buvaneswari Shanmugham; Archana Pan
Journal:  PLoS One       Date:  2013-03-19       Impact factor: 3.240

6.  Bioprinted 3D Primary Liver Tissues Allow Assessment of Organ-Level Response to Clinical Drug Induced Toxicity In Vitro.

Authors:  Deborah G Nguyen; Juergen Funk; Justin B Robbins; Candace Crogan-Grundy; Sharon C Presnell; Thomas Singer; Adrian B Roth
Journal:  PLoS One       Date:  2016-07-07       Impact factor: 3.240
  6 in total

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