Literature DB >> 11327696

Cloning, mapping, genomic organization, and expression of mouse M-LP, a new member of the peroxisomal membrane protein Mpv17 domain family.

R Iida1, T Yasuda, E Tsubota, T Matsuki, K Kishi.   

Abstract

We have identified a mouse full-length cDNA and gene encoding a novel protein (M-LP), based on an expressed sequence tag (EST) sequence (GenBank Accession No. AI482564) obtained by differential display screening of age-dependently expressed genes in mouse kidney. The ML-P gene is composed of three exons, ranges over 5 kb on mouse chromosome 16B1-B2 and is expressed as two transcripts (1455 and 3058 bp), both of which include the same open-reading frame encoding 194 amino acids. M-LP is expressed mainly in kidney and spleen and shows age-dependent expression. M-LP has sequence homologies and membrane topologies very similar to the Mpv17 protein, a peroxisomal protein involved in the development of early-onset glomerulosclerosis. Search of the protein domain family database (ProDom) revealed that M-LP is a new member of the Mpv17 domain family (PD008400).

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Year:  2001        PMID： 11327696     DOI： 10.1006/bbrc.2001.4769

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  8 in total

Review 1.  Metabolite transport across the peroxisomal membrane.

Authors:  Wouter F Visser; Carlo W T van Roermund; Lodewijk Ijlst; Hans R Waterham; Ronald J A Wanders
Journal:  Biochem J       Date:  2007-01-15       Impact factor: 3.857

2.  Mpv17l protects against mitochondrial oxidative stress and apoptosis by activation of Omi/HtrA2 protease.

Authors:  Stefanie Krick; Shaolin Shi; Wenjun Ju; Christian Faul; Su-yi Tsai; Peter Mundel; Erwin P Böttinger
Journal:  Proc Natl Acad Sci U S A       Date:  2008-09-04       Impact factor: 11.205

3.  Abnormal basement membrane in the inner ear and the kidney of the Mpv17-/- mouse strain: ultrastructural and immunohistochemical investigations.

Authors:  Angela M Meyer zum Gottesberge; Heidi Felix
Journal:  Histochem Cell Biol       Date:  2005-07-26       Impact factor: 4.304

4.  A novel transcriptional repressor, Rhit, is involved in heat-inducible and age-dependent expression of Mpv17-like protein, a participant in reactive oxygen species metabolism.

Authors:  Reiko Iida; Misuzu Ueki; Toshihiro Yasuda
Journal:  Mol Cell Biol       Date:  2010-03-15       Impact factor: 4.272

5.  Gene expression of intracortical bone demonstrates loading-induced increases in Wnt1 and Ngf and inhibition of bone remodeling processes.

Authors:  Taylor L Harris; Matthew J Silva
Journal:  Bone       Date:  2021-05-21       Impact factor: 4.626

6.  Three Nonsynonymous Single Nucleotide Polymorphisms in the RhitH Gene Cause Reduction of the Repression Activity That Leads to Upregulation of M-LPH, a Participant in Mitochondrial Function.

Authors:  Reiko Iida; Misuzu Ueki; Junko Fujihara; Haruo Takeshita; Kaori Kimura-Kataoka; Toshihiro Yasuda
Journal:  Biores Open Access       Date:  2013-12-01

7.  Knockout of Mpv17-Like Protein (M-LPH) Gene in Human Hepatoma Cells Results in Impairment of mtDNA Integrity through Reduction of TFAM, OGG1, and LIG3 at the Protein Levels.

Authors:  Reiko Iida; Misuzu Ueki; Toshihiro Yasuda
Journal:  Oxid Med Cell Longev       Date:  2018-09-17       Impact factor: 6.543

8.  Identification of Novel Key Molecular Signatures in the Pathogenesis of Experimental Diabetic Kidney Disease.

Authors:  Meng Diao; Yimu Wu; Jialu Yang; Caiying Liu; Jinyuan Xu; Hongchao Jin; Juan Wang; Jieping Zhang; Furong Gao; Caixia Jin; Haibin Tian; Jingying Xu; Qingjian Ou; Ying Li; Guotong Xu; Lixia Lu
Journal:  Front Endocrinol (Lausanne)       Date:  2022-03-30       Impact factor: 5.555
  8 in total

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