Literature DB >> 11327602

Novel 5,5-disubstitutedpyrimidine-2,4,6-triones as selective MMP inhibitors.

L H Foley1, R Palermo, P Dunten, P Wang.   

Abstract

The 5,5-disubstitutedpyrimidine-2,4,6-triones represent a new class of MMP inhibitors showing selectivity for the gelatinases A and B, collagenase-3, and human neutrophil collagenase. The SAR presented here is in good agreement with an X-ray structure of compound 5 bound to the catalytic domain of stromelysin-1. While of the barbiturate structural class, compound 5 did not show any toxic or sedative effects.

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Year:  2001        PMID： 11327602     DOI： 10.1016/s0960-894x(01)00104-4

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  10 in total

Review 1.  Matrix metalloproteinase inhibitors as investigative tools in the pathogenesis and management of vascular disease.

Authors:  Mina M Benjamin; Raouf A Khalil
Journal:  Exp Suppl       Date:  2012

Review 2.  Matrix Metalloproteinase Inhibitors as Investigational and Therapeutic Tools in Unrestrained Tissue Remodeling and Pathological Disorders.

Authors:  Jie Liu; Raouf A Khalil
Journal:  Prog Mol Biol Transl Sci       Date:  2017-05-10       Impact factor: 3.622

3.  X-ray structure of a novel matrix metalloproteinase inhibitor complexed to stromelysin.

Authors:  P Dunten; U Kammlott; R Crowther; W Levin; L H Foley; P Wang; R Palermo
Journal:  Protein Sci       Date:  2001-05       Impact factor: 6.725

Review 4.  Matrix metalloproteinases as potential targets in the venous dilation associated with varicose veins.

Authors:  Arda Kucukguven; Raouf A Khalil
Journal:  Curr Drug Targets       Date:  2013-03       Impact factor: 3.465

5.  A new strategy for the synthesis of β-benzylmercaptoethylamine derivatives.

Authors:  Subrata Ghosh; Gregory P Tochtrop
Journal:  Tetrahedron Lett       Date:  2009-04       Impact factor: 2.415

6.  High throughput screening of potentially selective MMP-13 exosite inhibitors utilizing a triple-helical FRET substrate.

Authors:  Janelle L Lauer-Fields; Dmitriy Minond; Peter S Chase; Pierre E Baillargeon; S Adrian Saldanha; Roma Stawikowska; Peter Hodder; Gregg B Fields
Journal:  Bioorg Med Chem       Date:  2008-03-06       Impact factor: 3.641

7.  Insights into the complex formed by matrix metalloproteinase-2 and alloxan inhibitors: molecular dynamics simulations and free energy calculations.

Authors:  Ilenia Giangreco; Gianluca Lattanzi; Orazio Nicolotti; Marco Catto; Antonio Laghezza; Francesco Leonetti; Angela Stefanachi; Angelo Carotti
Journal:  PLoS One       Date:  2011-10-05       Impact factor: 3.240

8.  Direct Synthesis of 5-Aryl Barbituric Acids by Rhodium(II)-Catalyzed Reactions of Arenes with Diazo Compounds.

Authors:  Daniel Best; David J Burns; Hon Wai Lam
Journal:  Angew Chem Int Ed Engl       Date:  2015-05-08       Impact factor: 15.336

9.  Syntheses of Radioiodinated Pyrimidine-2,4,6-Triones as Potential Agents for Non-Invasive Imaging of Matrix Metalloproteinases.

Authors:  Hans-Jörg Breyholz; Klaus Kopka; Michael Schäfers; Stefan Wagner
Journal:  Pharmaceuticals (Basel)       Date:  2017-05-30

10.  Novel Barbiturate-Nitrate Compounds Inhibit the Upregulation of Matrix Metalloproteinase-9 Gene Expression in Intestinal Inflammation through a cGMP-Mediated Pathway.

Authors:  Shane O'Sullivan; Jun Wang; Marek W Radomski; John F Gilmer; Carlos Medina
Journal:  Biomolecules       Date:  2020-05-25
  10 in total

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