| Literature DB >> 11327596 |
A Di Stefano1, B Mosciatti, G M Cingolani, G Giorgioni, M Ricciutelli, I Cacciatore, P Sozio, F Claudi.
Abstract
A series of dimeric derivatives (+)-1, and (+)-2, and (+)-3a-d of L-Dopa diacetyl esters was synthesized and evaluated as potential L-Dopa prodrugs with improved physicochemical properties. All the new compounds showed chemical stability in aqueous buffer solutions (pH 1.3 and 7.4). A relatively slow release of L-Dopa in human plasma was observed.Entities:
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Year: 2001 PMID： 11327596 DOI： 10.1016/s0960-894x(01)00140-8
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823