| Literature DB >> 11327581 |
H Beaton1, N Boughton-Smith, P Hamley, A Ghelani, D J Nicholls, A C Tinker, A V Wallace.
Abstract
5-Substituted 7-amino-4,5-tetrahydrothieno[2,3-c]pyridines and 6-substituted 4-amino-6,7-dihydrothieno[3,2-c]pyridines were shown to be exceptionally potent inhibitors of inducible and neuronal nitric oxide synthase. Selectivity and potency could be modulated by variation of the 5- or 6-substituent. Compound 3e showed potent in vivo inhibition of iNOS.Entities:
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Year: 2001 PMID： 11327581 DOI： 10.1016/s0960-894x(01)00120-2
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823