Literature DB >> 11327580

3,4-Dihydro-1-isoquinolinamines: a novel class of nitric oxide synthase inhibitors with a range of isoform selectivity and potency.

H Beaton1, P Hamley, D J Nicholls, A C Tinker, A V Wallace.   

Abstract

3-Phenyl-3.4-dihydro-1-isoquinolinamine is a weak inhibitor of iNOS and nNOS. Structural variation of 5a results in inhibitors with a range of potency and selectivity for the NOS enzymes, including a potent and very selective iNOS inhibitor 5j.

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Year:  2001        PMID： 11327580     DOI： 10.1016/s0960-894x(01)00119-6

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

Review 1.  Inducible nitric oxide synthase: Regulation, structure, and inhibition.

Authors:  Maris A Cinelli; Ha T Do; Galen P Miley; Richard B Silverman
Journal:  Med Res Rev       Date:  2019-06-13       Impact factor: 12.944

2.  Design and synthesis of 2-amino-4-methylpyridine analogues as inhibitors for inducible nitric oxide synthase and in vivo evaluation of [18F]6-(2-fluoropropyl)-4-methyl-pyridin-2-amine as a potential PET tracer for inducible nitric oxide synthase.

Authors:  Dong Zhou; Hsiaoju Lee; Justin M Rothfuss; Delphine L Chen; Datta E Ponde; Michael J Welch; Robert H Mach
Journal:  J Med Chem       Date:  2009-04-23       Impact factor: 7.446

3.  Design of benzene-1,2-diamines as selective inducible nitric oxide synthase inhibitors: a combined de novo design and docking analysis.

Authors:  Sandrea M Francis; Amit Mittal; Manishika Sharma; Prasad V Bharatam
Journal:  J Mol Model       Date:  2008-01-12       Impact factor: 1.810

4.  Isoquinolinamine FX-9 Exhibits Anti-Mitotic Activity in Human and Canine Prostate Carcinoma Cell Lines.

Authors:  Jan Torben Schille; Ingo Nolte; Eva-Maria Packeiser; Laura Wiesner; Jens Ingo Hein; Franziska Weiner; Xiao-Feng Wu; Matthias Beller; Christian Junghanss; Hugo Murua Escobar
Journal:  Int J Mol Sci       Date:  2019-11-07       Impact factor: 5.923
  4 in total

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