Literature DB >> 11327575

Stereocontrolled synthesis of LNA dinucleoside phosphorothioate by the oxathiaphospholane approach.

B Karwowski1, A Okruszek, J Wengel, W J Stec.   

Abstract

The application of the oxathiaphospholane approach for the stereocontrolled synthesis of LNA dinucleoside phosphorothioate is described. The reaction of ring opening condensation proceeds in CH3CN solution in high yield and with over 96% stereoselectivity. One of diastereomers of LNA dinucleoside phosphorothioate (presumably R(P)) was found to be readily digested by svPDE.

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Year:  2001        PMID： 11327575     DOI： 10.1016/s0960-894x(01)00109-3

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  2 in total

1.  P-stereocontrolled synthesis of oligo(nucleoside N3'→O5' phosphoramidothioate)s - opportunities and limitations.

Authors:  Ewa Radzikowska; Renata Kaczmarek; Dariusz Korczyński; Agnieszka Krakowiak; Barbara Mikołajczyk; Janina Baraniak; Piotr Guga; Kraig A Wheeler; Tomasz Pawlak; Barbara Nawrot
Journal:  RSC Adv       Date:  2020-09-23       Impact factor: 4.036

2.  Electronic Structures of LNA Phosphorothioate Oligonucleotides.

Authors:  Henrik G Bohr; Irene Shim; Cy Stein; Henrik Ørum; Henrik F Hansen; Troels Koch
Journal:  Mol Ther Nucleic Acids       Date:  2017-06-01       Impact factor: 8.886
  2 in total

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