Literature DB >> 11327317

Mitochondrial production of hydrogen peroxide regulation by nitric oxide and the role of ubisemiquinone.

A Boveris1, E Cadenas.   

Abstract

Mitochondria are considered the major cellular site for hydrogen peroxide production, a process that is kinetically controlled by the availability of oxygen and nitric oxide to cytochrome oxidase and of ADP to F1-ATPase. The multisite regulation of mitochondrial respiration and energy-transducing pathways support a critical regulatory role of mitochondrion in cell signaling pathways. The cellular steady-state levels of hydrogen peroxide and the role of mitochondria in maintaining these levels are reviewed.

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Year:  2000        PMID: 11327317     DOI: 10.1080/713803732

Source DB:  PubMed          Journal:  IUBMB Life        ISSN: 1521-6543            Impact factor:   3.885


  35 in total

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