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Literature DB >> 11327152

Signal-regulated ADF/cofilin activity and growth cone motility.

Abstract

It is becoming increasingly evident that proteins of the actin depolymerizing factor (ADF)/cofilin family are essential regulators of actin turnover required for many actin-based cellular processes, including motility. ADF can increase actin turnover by either increasing the rate of actin filament treadmilling or by severing actin filaments. In neurons ADF is highly expressed in neuronal growth cones and its activity is regulated by many signals that affect growth cone motility. In addition, increased activity of ADF causes an increase in neurite extension. ADF activity is inhibited upon phosphorylation by LIM kinases (LIMK), kinases activated by members of the Rho family of small GTPases. ADF become dephosphorylated downstream of signal pathways that activate PI-3 kinase or increase levels of intracellular calcium. The growth-regulating effects of ADF together with its ability to be regulated by a wide variety of guidance cues, suggest that ADF may regulate growth cone advance and navigation.

Entities: Chemical

Mesh：

Substances：

Year: 2000 PMID： 11327152 DOI： 10.1385/MN:21:1-2:097

Source DB: PubMed Journal: Mol Neurobiol ISSN： 0893-7648 Impact factor: 5.682

67 in total

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Journal: Science Date: 1988-11-04 Impact factor: 47.728

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Journal: J Neurosci Date: 1999-09-15 Impact factor: 6.167

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Journal: J Cell Sci Date: 1996-02 Impact factor: 5.285

10 in total

1. Control of growth cone motility and morphology by LIM kinase and Slingshot via phosphorylation and dephosphorylation of cofilin.

Authors: Mitsuharu Endo; Kazumasa Ohashi; Yukio Sasaki; Yoshio Goshima; Ryusuke Niwa; Tadashi Uemura; Kensaku Mizuno
Journal: J Neurosci Date: 2003-04-01 Impact factor: 6.167

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Authors: Mayssa H Mokalled; Aaron Johnson; Yuri Kim; Jiyeon Oh; Eric N Olson
Journal: Development Date: 2010-06-09 Impact factor: 6.868

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Journal: Neuron Date: 2019-08-07 Impact factor: 17.173

4. The actin-binding protein UNC-115/abLIM controls formation of lamellipodia and filopodia and neuronal morphogenesis in Caenorhabditis elegans.

Authors: Yieyie Yang; Erik A Lundquist
Journal: Mol Cell Biol Date: 2005-06 Impact factor: 4.272

5. EGF Downregulates Presynaptic Maturation and Suppresses Synapse Formation In Vitro and In Vivo.

Authors: Nobuyuki Takei; Daisaku Yokomaku; Takaho Yamada; Tadasato Nagano; Akiyoshi Kakita; Hisaaki Namba; Tatsuo Ushiki; Hitoshi Takahashi; Hiroyuki Nawa
Journal: Neurochem Res Date: 2022-01-04 Impact factor: 4.414

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Journal: Neuroscience Date: 2008-01-12 Impact factor: 3.590