Literature DB >> 11326683

Expression of the Thomsen-Friedenreich (TF) antigen in the human placenta.

D U Richter1, U Jeschke, J Makovitzky, S Goletz, U Karsten, V Briese, K Friese.   

Abstract

The Thomsen-Friedenreich (TF) antigen (or, more precisely, epitope; Gal beta 1-3GalNAc-) has been known for a long time as a pancarcinoma antigen. Here we report the immunohistochemical identification of this carbohydrate antigen in the human placenta. Paraffin-embedded placental and decidual tissues of the first, second and third trimester were incubated with different monoclonal antibodies (A78-G/A7 and HH8) directed against the TF-epitope and stained with an immunohistochemistry system. We found a strong expression of the TF-epitope in the first trimester of pregnancy. In addition, we identified an expression of the TF-antigen in the second trimester of pregnancy but only in a few cases a positive staining in the third trimester of pregnancy.

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Year:  2000        PMID： 11326683

Source DB:  PubMed          Journal:  Anticancer Res        ISSN： 0250-7005            Impact factor:   2.480


  8 in total

1.  Binding of galectin-1 (gal-1) to the Thomsen-Friedenreich (TF) antigen on trophoblast cells and inhibition of proliferation of trophoblast tumor cells in vitro by gal-1 or an anti-TF antibody.

Authors:  Udo Jeschke; Uwe Karsten; Irmi Wiest; Sandra Schulze; Christina Kuhn; Klaus Friese; Hermann Walzel
Journal:  Histochem Cell Biol       Date:  2006-04-11       Impact factor: 4.304

2.  Binding of galectin-1 (gal-1) on trophoblast cells and inhibition of hormone production of trophoblast tumor cells in vitro by gal-1.

Authors:  Udo Jeschke; Toralf Reimer; Claudia Bergemann; Irmi Wiest; Sandra Schulze; Klaus Friese; Hermann Walzel
Journal:  Histochem Cell Biol       Date:  2004-06-08       Impact factor: 4.304

3.  The human endometrium expresses the glycoprotein mucin-1 and shows positive correlation for Thomsen-Friedenreich epitope expression and galectin-1 binding.

Authors:  Udo Jeschke; Hermann Walzel; Ioannis Mylonas; Panos Papadopoulos; Naim Shabani; Christina Kuhn; Sandra Schulze; Klaus Friese; Uwe Karsten; David Anz; Markus S Kupka
Journal:  J Histochem Cytochem       Date:  2009-06-08       Impact factor: 2.479

4.  Fap2 Mediates Fusobacterium nucleatum Colorectal Adenocarcinoma Enrichment by Binding to Tumor-Expressed Gal-GalNAc.

Authors:  Jawad Abed; Johanna E M Emgård; Gideon Zamir; Mouhammad Faroja; Gideon Almogy; Amalie Grenov; Asaf Sol; Ronit Naor; Eli Pikarsky; Karine A Atlan; Anna Mellul; Stella Chaushu; Abigail L Manson; Ashlee M Earl; Nora Ou; Caitlin A Brennan; Wendy S Garrett; Gilad Bachrach
Journal:  Cell Host Microbe       Date:  2016-08-10       Impact factor: 21.023

5.  Diagnostic value of lectins in differentiation of molar placentas.

Authors:  Fatemeh Atabaki Pasdar; Alireza Khooei; Alireza Fazel; Mahmoud Mahmoudi; Mohammad Reza Nikravesh; Mohammad Khaje Delui
Journal:  Iran J Basic Med Sci       Date:  2012-11       Impact factor: 2.699

Review 6.  Fusobacterium nucleatum and cancer.

Authors:  Tamar Alon-Maimon; Ofer Mandelboim; Gilad Bachrach
Journal:  Periodontol 2000       Date:  2022-03-04       Impact factor: 12.239

7.  Detection of sugar chain expression in hydatidiform mole using lectin histochemistry.

Authors:  Fatemeh Atabaki Pasdar; Alireza Khooei; Alireza Fazel; Mahmoud Mahmoudi; Fatemeh Tavassoli
Journal:  Iran Red Crescent Med J       Date:  2013-05-05       Impact factor: 0.611

Review 8.  Profiling of Naturally Occurring Antibodies to the Thomsen-Friedenreich Antigen in Health and Cancer: The Diversity and Clinical Potential.

Authors:  Oleg Kurtenkov
Journal:  Biomed Res Int       Date:  2020-03-23       Impact factor: 3.411
  8 in total

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