Literature DB >> 1132634

Comparison of secretin and vasoactive intestinal peptide on pancreatic secretion in dogs.

S J Konturek, P Thor, A Dembinski, R Krol.   

Abstract

Vasoactive inhibitory peptide (VIP) and secretin were compared in regard to the stimulation of pancreatic bicarbonate secretion and the augmentation of pancreatic response to caerulein or a peptone meal in chronic gastric and pancreatic fistula dogs. Dose-response analysis showed that maximal bicarbonate response to VIP was about 17% of that to secretin. Both caerulein and endogenous cholecystokinin, released by a peptone meal, clearly potentiated pancreatic bicarbonate response to VIP in a manner similar to secretin. The interactions of these two peptides showed that VIP is a potent inhibitor of secretin-induced pancreatic secretion. From the dose-response curves to secretin alone and secretin plus VIP, Michaelis-Menten analysis showed typical competitive inhibition, which indicates that VIP and secretin share a common receptor site.

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Year:  1975        PMID： 1132634

Source DB:  PubMed          Journal:  Gastroenterology        ISSN： 0016-5085            Impact factor:   22.682


  15 in total

1.  Current concepts of neuro-hormonal control of pancreatic secretion.

Authors:  S J Konturek
Journal:  Ir J Med Sci       Date:  1978-01       Impact factor: 1.568

2.  Effect of duodenal osmolality on gastrin and secretin release and on gastric and pancreatic secretion.

Authors:  R K Teichmann; J S Swierczek; P L Rayford; J C Thompson
Journal:  World J Surg       Date:  1979-09-20       Impact factor: 3.352

3.  The effect of fat on secretin release.

Authors:  T A Miller; S J Konturek; O L Llanos; P L Rayford; J C Thompson
Journal:  Ann Surg       Date:  1978-03       Impact factor: 12.969

4.  Comparison of vasoactive intestinal peptide and secretin in stimulation of pancreatic secretion.

Authors:  S J Konturek; A Pucher; T Radecki
Journal:  J Physiol       Date:  1976-02       Impact factor: 5.182

5.  Effects of CCK-8 in combination with natural or synthetic secretin on amylase, lipase, trypsin, and chymotrypsin secretion in rats.

Authors:  T Rösch; V Schusdziarra; A Wolf; M Classen
Journal:  Int J Pancreatol       Date:  1989-10

6.  A vasopressin-induced decrease in pancreatic blood flow and in pancreatic exocrine secretion in the anesthetized dog.

Authors:  H J Beijer; A H Maas; G A Charbon
Journal:  Pflugers Arch       Date:  1984-03       Impact factor: 3.657

7.  Enhancement by atropine of the pancreatic exocrine secretions evoked by vagal stimulation in the pithed rat.

Authors:  J Barrett; J J McDougall; J D Morrison
Journal:  J Physiol       Date:  1993-09       Impact factor: 5.182

8.  Pancreatic exocrine secretion and immunoreactive secretin release after intraduodenal instillation of 1-phenyl-1-hydroxy-n-pentane and HCl in rats.

Authors:  M Otsuki; C Sakamoto; A Ohki; H Yuu; M Maeda; S Baba
Journal:  Dig Dis Sci       Date:  1981-06       Impact factor: 3.199

9.  Primary Pancreatic Secretinoma: Further Evidence Supporting Secretin as a Diarrheogenic Hormone.

Authors:  William Y Chey; Wendy L Frankel; Sashwati Roy; Soma Datta; Chandan K Sen; Mary Dillhoff; Peter Muscarella; Konrad H Soergel; Ronald K Tompkins; Ta-Min Chang; Edward L Bradley; Edwin Christopher Ellison
Journal:  Ann Surg       Date:  2017-08       Impact factor: 12.969

10.  Origin and distribution of VIP (vasoactive intestinal polypeptide)-nerves in the genito-urinary tract.

Authors:  P Alm; J Alumets; R Håkanson; O Owman; N O Sjöberg; F Sundler; B Walles
Journal:  Cell Tissue Res       Date:  1980       Impact factor: 5.249
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