Literature DB >> 11325631

Clinical application of pharmacogenetics.

B B Spear1, M Heath-Chiozzi, J Huff.   

Abstract

Pharmacogenetics encompasses the involvement of genes in an individual's response to drugs. As such, the field covers a vast area including basic drug discovery research, the genetic basis of pharmacokinetics and pharmacodynamics, new drug development, patient genetic testing and clinical patient management. Ultimately, the goal of pharmacogenetics is to predict a patient's genetic response to a specific drug as a means of delivering the best possible medical treatment. By predicting the drug response of an individual, it will be possible to increase the success of therapies and reduce the incidence of adverse side effects.

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Year:  2001        PMID: 11325631     DOI: 10.1016/s1471-4914(01)01986-4

Source DB:  PubMed          Journal:  Trends Mol Med        ISSN: 1471-4914            Impact factor:   11.951


  116 in total

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2.  Theoretical basis for the identification of allelic variants that encode drug efficacy and toxicity.

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3.  CYP2D6 polymorphisms in patients with porphyrias.

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4.  TYMS and DPYD polymorphisms in a Turkish population.

Authors:  H S Süzen; N Yüce; G Güvenç; Y Duydu; T Erke
Journal:  Eur J Clin Pharmacol       Date:  2005-11-17       Impact factor: 2.953

5.  The future costs, risks and rewards of drug development: the economics of pharmacogenomics.

Authors:  Joseph Cook; Graeme Hunter; John A Vernon
Journal:  Pharmacoeconomics       Date:  2009       Impact factor: 4.981

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8.  Personalized medicine in breast cancer: a systematic review.

Authors:  Sang-Hoon Cho; Jongsu Jeon; Seung Il Kim
Journal:  J Breast Cancer       Date:  2012-09-28       Impact factor: 3.588

9.  No influence of the polymorphisms CYP2C19 and CYP2D6 on the efficacy of cyclophosphamide, thalidomide, and bortezomib in patients with Multiple Myeloma.

Authors:  Annette J Vangsted; Karen Søeby; Tobias W Klausen; Niels Abildgaard; Niels F Andersen; Peter Gimsing; Henrik Gregersen; Ulla Vogel; Thomas Werge; Henrik B Rasmussen
Journal:  BMC Cancer       Date:  2010-08-04       Impact factor: 4.430

10.  Dealing with heterogeneity of treatment effects: is the literature up to the challenge?

Authors:  Nicole B Gabler; Naihua Duan; Diana Liao; Joann G Elmore; Theodore G Ganiats; Richard L Kravitz
Journal:  Trials       Date:  2009-06-19       Impact factor: 2.279

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