Literature DB >> 11325469

Immunoregulatory role of secreted glycoprotein G from respiratory syncytial virus.

R Ray1, D F Hoft, K Meyer, R Brown, L M Lagging, R B Belshe.   

Abstract

The secretory glycoprotein (Gs) of respiratory syncytial virus (RSV) was enriched and investigated for its effects on T cells specific for RSV and unrelated antigens. Gs exhibited a dose dependent suppression of lymphoproliferative responses in peripheral blood mononuclear cells (PBMCs), specific for mycobacterial lysates or tetanus toxoid. However, Gs did not inhibit live RSV specific T cell responses. These results suggest that Gs may suppress immune response to unrelated antigens, but should not interfere with the overall development of RSV specific immunity.

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Year:  2001        PMID： 11325469     DOI： 10.1016/s0168-1702(01)00237-4

Source DB:  PubMed          Journal:  Virus Res        ISSN： 0168-1702            Impact factor:   3.303


  10 in total

1.  CX3CR1 is an important surface molecule for respiratory syncytial virus infection in human airway epithelial cells.

Authors:  Tatiana Chirkova; Songbai Lin; Antonius G P Oomens; Kelsey A Gaston; Seyhan Boyoglu-Barnum; Jia Meng; Christopher C Stobart; Calvin U Cotton; Tina V Hartert; Martin L Moore; Assem G Ziady; Larry J Anderson
Journal:  J Gen Virol       Date:  2015-06-25       Impact factor: 3.891

2.  Mutating the CX3C Motif in the G Protein Should Make a Live Respiratory Syncytial Virus Vaccine Safer and More Effective.

Authors:  S Boyoglu-Barnum; S O Todd; J Meng; T R Barnum; T Chirkova; L M Haynes; S J Jadhao; R A Tripp; A G Oomens; M L Moore; L J Anderson
Journal:  J Virol       Date:  2017-04-28       Impact factor: 5.103

3.  A respiratory syncytial virus (RSV) anti-G protein F(ab')2 monoclonal antibody suppresses mucous production and breathing effort in RSV rA2-line19F-infected BALB/c mice.

Authors:  Seyhan Boyoglu-Barnum; Kelsey A Gaston; Sean O Todd; Cemil Boyoglu; Tatiana Chirkova; Thomas R Barnum; Patricia Jorquera; Lia M Haynes; Ralph A Tripp; Martin L Moore; Larry J Anderson
Journal:  J Virol       Date:  2013-07-24       Impact factor: 5.103

4.  An anti-G protein monoclonal antibody treats RSV disease more effectively than an anti-F monoclonal antibody in BALB/c mice.

Authors:  Seyhan Boyoglu-Barnum; Sean O Todd; Tatiana Chirkova; Thomas R Barnum; Kelsey A Gaston; Lia M Haynes; Ralph A Tripp; Martin L Moore; Larry J Anderson
Journal:  Virology       Date:  2015-05-15       Impact factor: 3.616

5.  Immunogenicity and protective efficacy of RSV G central conserved domain vaccine with a prefusion nanoparticle.

Authors:  Jennifer N Rainho-Tomko; Vincent Pavot; Michael Kishko; Kurt Swanson; Darin Edwards; Heesik Yoon; Lilibeth Lanza; Judith Alamares-Sapuay; Robert Osei-Bonsu; Sophia T Mundle; Dave A Murison; Scott Gallichan; Simon Delagrave; Chih-Jen Wei; Linong Zhang; Gary J Nabel
Journal:  NPJ Vaccines       Date:  2022-06-30       Impact factor: 9.399

6.  Prophylaxis with a respiratory syncytial virus (RSV) anti-G protein monoclonal antibody shifts the adaptive immune response to RSV rA2-line19F infection from Th2 to Th1 in BALB/c mice.

Authors:  Seyhan Boyoglu-Barnum; Tatiana Chirkova; Sean O Todd; Thomas R Barnum; Kelsey A Gaston; Patricia Jorquera; Lia M Haynes; Ralph A Tripp; Martin L Moore; Larry J Anderson
Journal:  J Virol       Date:  2014-07-02       Impact factor: 5.103

7.  The secreted form of respiratory syncytial virus G glycoprotein helps the virus evade antibody-mediated restriction of replication by acting as an antigen decoy and through effects on Fc receptor-bearing leukocytes.

Authors:  Alexander Bukreyev; Lijuan Yang; Jens Fricke; Lily Cheng; Jerrold M Ward; Brian R Murphy; Peter L Collins
Journal:  J Virol       Date:  2008-10-08       Impact factor: 5.103

8.  Respiratory syncytial virus G protein CX3C motif impairs human airway epithelial and immune cell responses.

Authors:  Tatiana Chirkova; Seyhan Boyoglu-Barnum; Kelsey A Gaston; Fahad M Malik; Steven P Trau; Antonius G P Oomens; Larry J Anderson
Journal:  J Virol       Date:  2013-10-02       Impact factor: 5.103

9.  Use of a novel cell-based fusion reporter assay to explore the host range of human respiratory syncytial virus F protein.

Authors:  Patrick J Branigan; Changbao Liu; Nicole D Day; Lester L Gutshall; Robert T Sarisky; Alfred M Del Vecchio
Journal:  Virol J       Date:  2005-07-13       Impact factor: 4.099

Review 10.  Functional Features of the Respiratory Syncytial Virus G Protein.

Authors:  Larry J Anderson; Samadhan J Jadhao; Clinton R Paden; Suxiang Tong
Journal:  Viruses       Date:  2021-07-01       Impact factor: 5.048
  10 in total

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