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Literature DB >> 11325242

New macrolides and furan carboxylic acid derivative from the sponge-derived fungus Cladosporium herbarum.

R Jadulco¹, P Proksch, V Wray, A Berg, U Gräfe.

Abstract

Bioassay-guided fractionation of organic extracts of Cladosporium herbarum, isolated from the marine sponge Callyspongia aerizusa, yielded two new macrolide metabolites: pandangolide 3 and 4 (1 and 2) and the known fungal metabolites pandangolide 2 (3), cladospolide B (4), and iso-cladospolide B (5). Also isolated were the antimicrobially active (against Bacillus subtilis and Staphylococcus aureus) furan carboxylic acids: Sumiki's acid (6) and its new derivative, acetyl Sumiki's acid (7). All structures were elucidated by spectroscopic methods.

Entities: Chemical Species

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Year: 2001 PMID： 11325242 DOI： 10.1021/np000401s

Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050

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Cited

19 in total

Review 1. Marine pharmacology in 2001--2002: marine compounds with anthelmintic, antibacterial, anticoagulant, antidiabetic, antifungal, anti-inflammatory, antimalarial, antiplatelet, antiprotozoal, antituberculosis, and antiviral activities; affecting the cardiovascular, immune and nervous systems and other miscellaneous mechanisms of action.

Authors: Alejandro M S Mayer; Mark T Hamann
Journal: Comp Biochem Physiol C Toxicol Pharmacol Date: 2005 Mar-Apr Impact factor: 3.228

Review 2. Sponge-associated microorganisms: evolution, ecology, and biotechnological potential.

Authors: Michael W Taylor; Regina Radax; Doris Steger; Michael Wagner
Journal: Microbiol Mol Biol Rev Date: 2007-06 Impact factor: 11.056

3. Methods for isolation of marine-derived endophytic fungi and their bioactive secondary products.

Authors: Julia Kjer; Abdessamad Debbab; Amal H Aly; Peter Proksch
Journal: Nat Protoc Date: 2010-02-18 Impact factor: 13.491

4. The first total synthesis of sporiolide A.

Authors: Yuguo Du; Qi Chen; Robert J Linhardt
Journal: J Org Chem Date: 2006-10-27 Impact factor: 4.354

5. The Berkeleylactones, Antibiotic Macrolides from Fungal Coculture.

Authors: Andrea A Stierle; Donald B Stierle; Daniel Decato; Nigel D Priestley; Jeremy B Alverson; John Hoody; Kelly McGrath; Dorota Klepacki
Journal: J Nat Prod Date: 2017-03-22 Impact factor: 4.050

Review 6. Untapped Potential of Marine-Associated Cladosporium Species: An Overview on Secondary Metabolites, Biotechnological Relevance, and Biological Activities.

Authors: Gamal A Mohamed; Sabrin R M Ibrahim
Journal: Mar Drugs Date: 2021-11-18 Impact factor: 5.118

New macrolides and furan carboxylic acid derivative from the sponge-derived fungus Cladosporium herbarum.

Review 2. Sponge-associated microorganisms: evolution, ecology, and biotechnological potential.

3. Methods for isolation of marine-derived endophytic fungi and their bioactive secondary products.

4. The first total synthesis of sporiolide A.

5. The Berkeleylactones, Antibiotic Macrolides from Fungal Coculture.

Review 6. Untapped Potential of Marine-Associated Cladosporium Species: An Overview on Secondary Metabolites, Biotechnological Relevance, and Biological Activities.

Review 7. Marine drugs from sponge-microbe association--a review.

8. Palladium-catalyzed asymmetric allylic alkylation of meso- and dl-1,2-divinylethylene carbonate.

Review 9. The current status of natural products from marine fungi and their potential as anti-infective agents.

Review 10. The Genus Cladosporium: A Rich Source of Diverse and Bioactive Natural Compounds.