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Literature DB >> 11325241

Microxine, a new cdc2 kinase inhibitor from the Australian marine sponge Microxina species.

K B Killday¹, D Yarwood, M A Sills, P T Murphy, J N Hooper, A E Wright.

Abstract

A new purine derivative microxine (1) was isolated from the Australian marine sponge Microxina sp. The compound was isolated via reversed-phase chromatography and its structure determined spectroscopically. Microxine was found to weakly inhibit cdc2 kinase activity with an IC(50) of 13 microM.

Entities: Chemical Gene

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Year: 2001 PMID： 11325241 DOI： 10.1021/np000546z

Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050

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Cited

7 in total

1. Novel N-methylated 8-oxoisoguanines from Pacific sponges with diverse neuroactivities.

Authors: Tsuyoshi Sakurada; Martin B Gill; Shanti Frausto; Bryan Copits; Keiichi Noguchi; Keiko Shimamoto; Geoffrey T Swanson; Ryuichi Sakai
Journal: J Med Chem Date: 2010-08-26 Impact factor: 7.446

Review 2. Mechanism targeted discovery of antitumor marine natural products.

Authors: Dale G Nagle; Yu-Dong Zhou; Flor D Mora; Kaleem A Mohammed; Yong-Pil Kim
Journal: Curr Med Chem Date: 2004-07 Impact factor: 4.530

3. Isolation, synthesis, and biological activity of aphrocallistin, an adenine-substituted bromotyramine metabolite from the Hexactinellida sponge Aphrocallistes beatrix.

Authors: Amy E Wright; Gregory P Roth; Jennifer K Hoffman; Daniela B Divlianska; Diana Pechter; Susan H Sennett; Esther A Guzmán; Patricia Linley; Peter J McCarthy; Tara P Pitts; Shirley A Pomponi; John K Reed
Journal: J Nat Prod Date: 2009-06 Impact factor: 4.050

Microxine, a new cdc2 kinase inhibitor from the Australian marine sponge Microxina species.

1. Novel N-methylated 8-oxoisoguanines from Pacific sponges with diverse neuroactivities.

Review 2. Mechanism targeted discovery of antitumor marine natural products.

3. Isolation, synthesis, and biological activity of aphrocallistin, an adenine-substituted bromotyramine metabolite from the Hexactinellida sponge Aphrocallistes beatrix.

Review 4. Kinase inhibitors from marine sponges.

Review 5. Marine Alkylpurines: A Promising Group of Bioactive Marine Natural Products.

Review 6. Sponges: A Reservoir of Genes Implicated in Human Cancer.

Review 7. Marine Sponges and Bacteria as Challenging Sources of Enzyme Inhibitors for Pharmacological Applications.