Non-invasive determination of muscle blood flow in the extremities from laser Doppler spectra.

We investigate theoretically the non-invasive determination of blood flow in muscles of the extremities using laser Doppler measurements. Laser Doppler spectra are calculated using Monte Carlo simulations and solutions of the correlation diffusion equation. The extremities are modelled as a two-layered turbid medium. The first layer represents the skin and subcutaneous fat layer and the second layer the muscle. It is shown that the absolute root-mean-square velocity of the blood in the muscle layer can be accurately derived in many practical cases if the laser Doppler spectra are measured at a distance which is sufficiently far from the source, and if the optical properties of the muscle are simultaneously determined.