Literature DB >> 11324918

Antimicrobial alkaloids from Zanthoxylum tetraspermum and caudatum.

A P Nissanka1, V Karunaratne, B M Bandara, V Kumar, T Nakanishi, M Nishi, A Inada, L M Tillekeratne, D S Wijesundara, A A Gunatilaka.   

Abstract

Two benzophenanthrene alkaloids, 8-acetonyldihydronitidine and 8-acetonyldihydroavicine were isolated from Zanthoxylum tetraspermum stem bark along with liriodenine, sesamin, lichexanthone and (+)-piperitol-gamma,gamma-dimethylallylether. The species endemic to Sri Lanka, Z. caudatum, contained sesamin, savinin, liriodenine, decarine and 8-O-desmethyl-N-nornitidine. 8-Acetonyldihydronitidine and 8-acetonyldihydroavicine showed significant antibacterial activity while the former along with liriodenine was strongly antifungal. Savinin exhibited potent spermicidal activity. Both savinin and sesamin exhibited significant insecticidal activity.

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Year:  2001        PMID： 11324918     DOI： 10.1016/s0031-9422(00)00402-7

Source DB:  PubMed          Journal:  Phytochemistry        ISSN： 0031-9422            Impact factor:   4.072


  12 in total

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