| Literature DB >> 11323712 |
Y Shi1.
Abstract
Mitochondria-mediated apoptosis plays a central role in animal development and tissue homeostasis, and its alteration results in a range of malignant disorders including cancer. Upon apoptotic stimuli, the mitochondrial proteins cytochrome c and Smac/DIABLO are released into the cytosol, where they synergistically activate caspases by activating Apaf-1 and relieving the apoptotic inhibition by IAPs. Recent biochemical and structural studies reveal a molecular basis for these important events and identify an evolutionarily conserved mechanism of apoptosis from fruit flies to mammals.Entities:
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Year: 2001 PMID： 11323712 DOI： 10.1038/87548
Source DB: PubMed Journal: Nat Struct Biol ISSN： 1072-8368