PURPOSE: To evaluate quantitative Doppler ultrasonography (US) for assessing renal blood flow changes induced with endothelin-1 (ET-1) and fenoldopam mesylate in conscious dogs. MATERIALS AND METHODS: A blood flow probe was surgically implanted around the renal artery in eight adult dogs. Color and power Doppler US images were acquired in conscious restrained dogs during intravenous infusion of ET-1 and fenoldopam mesylate. Simultaneous with imaging, blood flow through the renal artery was measured with the implanted probe. The color level of the images within the region representing the kidney was analyzed to derive flow indices. These indices were compared with direct-flow measurements. RESULTS: The flow indices, color-weighted flow area (CWFA), and percentage of area of color, derived from color and power Doppler US images, correlated linearly with direct flow. The mean color level of color and power Doppler US images correlated weakly with direct flow. Pre- versus postinfusion CWFA decreased with all ET-1 infusions (P < or =.032). Infusion of fenoldopam mesylate increased CWFA in all cases (P < or =.032). CONCLUSION: Quantitative Doppler US enabled successful measurement of the flow changes induced with ET-1 and fenoldopam mesylate. Quantitative Doppler US is potentially useful as a noninvasive surrogate endpoint in evaluating the action of various therapeutic agents.
PURPOSE: To evaluate quantitative Doppler ultrasonography (US) for assessing renal blood flow changes induced with endothelin-1 (ET-1) and fenoldopam mesylate in conscious dogs. MATERIALS AND METHODS: A blood flow probe was surgically implanted around the renal artery in eight adult dogs. Color and power Doppler US images were acquired in conscious restrained dogs during intravenous infusion of ET-1 and fenoldopam mesylate. Simultaneous with imaging, blood flow through the renal artery was measured with the implanted probe. The color level of the images within the region representing the kidney was analyzed to derive flow indices. These indices were compared with direct-flow measurements. RESULTS: The flow indices, color-weighted flow area (CWFA), and percentage of area of color, derived from color and power Doppler US images, correlated linearly with direct flow. The mean color level of color and power Doppler US images correlated weakly with direct flow. Pre- versus postinfusion CWFA decreased with all ET-1 infusions (P < or =.032). Infusion of fenoldopam mesylate increased CWFA in all cases (P < or =.032). CONCLUSION: Quantitative Doppler US enabled successful measurement of the flow changes induced with ET-1 and fenoldopam mesylate. Quantitative Doppler US is potentially useful as a noninvasive surrogate endpoint in evaluating the action of various therapeutic agents.
Authors: Corinne N Riggin; Stephanie N Weiss; Ashley B Rodriguez; Harina Raja; Mengcun Chen; Susan M Schultz; Chandra M Sehgal; Louis J Soslowsky Journal: Ann Biomed Eng Date: 2022-03-18 Impact factor: 4.219
Authors: Andrew K W Wood; Ralph M Bunte; Heather E Price; Margaret S Deitz; Jeff H Tsai; William M-F Lee; Chandra M Sehgal Journal: Acad Radiol Date: 2008-09 Impact factor: 3.173
Authors: Andrew K W Wood; Ralph M Bunte; Jennie D Cohen; Jeff H Tsai; William M-F Lee; Chandra M Sehgal Journal: Ultrasound Med Biol Date: 2007-08-27 Impact factor: 2.998
Authors: George J Cerniglia; Nabendu Pore; Jeff H Tsai; Susan Schultz; Rosemarie Mick; Regine Choe; Xiaoman Xing; Turgut Durduran; Arjun G Yodh; Sydney M Evans; Cameron J Koch; Stephen M Hahn; Harry Quon; Chandra M Sehgal; William M F Lee; Amit Maity Journal: PLoS One Date: 2009-08-06 Impact factor: 3.240
Authors: Gabriela S Seiler; Lisa S Ziemer; Susan Schultz; William M F Lee; Chandra M Sehgal Journal: Cancer Imaging Date: 2007-12-17 Impact factor: 3.909
Authors: Corinne N Riggin; Ashley B Rodriguez; Stephanie N Weiss; Harina A Raja; Mengcun Chen; Susan M Schultz; Chandra M Sehgal; Louis J Soslowsky Journal: J Orthop Res Date: 2020-10-01 Impact factor: 3.102