Literature DB >> 11323305

Is lipophosphoglycan a virulence factor? A surprising diversity between Leishmania species.

S J Turco1, G F Späth, S M Beverley.   

Abstract

Lipophosphoglycan is a prominent member of the phosphoglycan-containing surface glycoconjugates of Leishmania. Genetic tests enable confirmation of its role in parasite virulence and permit discrimination between the roles of lipophosphoglycan and related glycoconjugates. When two different lipophosphoglycan biosynthetic genes from Leishmania major were knocked out, there was a clear loss of virulence in several steps of the infectious cycle but, with Leishmania mexicana, no effect on virulence was found. This points to an unexpected diversity in the reliance of Leishmania species on virulence factors, a finding underscored by recent studies showing great diversity in the host response to Leishmania species.

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Year:  2001        PMID： 11323305     DOI： 10.1016/s1471-4922(01)01895-5

Source DB:  PubMed          Journal:  Trends Parasitol        ISSN： 1471-4922


  48 in total

1.  Probing elongating and branching β-D-galactosyltransferase activities in Leishmania parasites by making use of synthetic phosphoglycans.

Authors:  Olga V Sizova; Andrew J Ross; Irina A Ivanova; Vladimir S Borodkin; Michael A J Ferguson; Andrei V Nikolaev
Journal:  ACS Chem Biol       Date:  2011-04-11       Impact factor: 5.100

2.  Infection with arginase-deficient Leishmania major reveals a parasite number-dependent and cytokine-independent regulation of host cellular arginase activity and disease pathogenesis.

Authors:  Helen M Muleme; Rosa M Reguera; Alicia Berard; Richard Azinwi; Ping Jia; Ifeoma B Okwor; Stephen Beverley; Jude E Uzonna
Journal:  J Immunol       Date:  2009-12-15       Impact factor: 5.422

3.  Trichomonas vaginalis lipophosphoglycan mutants have reduced adherence and cytotoxicity to human ectocervical cells.

Authors:  Felix D Bastida-Corcuera; Cheryl Y Okumura; Angie Colocoussi; Patricia J Johnson
Journal:  Eukaryot Cell       Date:  2005-11

4.  The genetic toolbox for Leishmania parasites.

Authors:  Sigrid C Roberts
Journal:  Bioeng Bugs       Date:  2011-11-01

5.  Pathogen-derived oligosaccharides improve innate immune response to intracellular parasite infection.

Authors:  Alex Osanya; Eun-Ho Song; Kyle Metz; Raeann M Shimak; Paola Mercedes Boggiatto; Elise Huffman; Charles Johnson; Jesse M Hostetter; Nicola L B Pohl; Christine A Petersen
Journal:  Am J Pathol       Date:  2011-07-16       Impact factor: 4.307

6.  Proteophosphoglycan confers resistance of Leishmania major to midgut digestive enzymes induced by blood feeding in vector sand flies.

Authors:  Nagila Secundino; Nicola Kimblin; Nathan C Peters; Phillip Lawyer; Althea A Capul; Stephen M Beverley; Salvatore J Turco; David Sacks
Journal:  Cell Microbiol       Date:  2010-01-20       Impact factor: 3.715

7.  The role(s) of lipophosphoglycan (LPG) in the establishment of Leishmania major infections in mammalian hosts.

Authors:  Gerald F Späth; L A Garraway; Salvatore J Turco; Stephen M Beverley
Journal:  Proc Natl Acad Sci U S A       Date:  2003-07-17       Impact factor: 11.205

8.  Retention and loss of RNA interference pathways in trypanosomatid protozoans.

Authors:  Lon-Fye Lye; Katherine Owens; Huafang Shi; Silvane M F Murta; Ana Carolina Vieira; Salvatore J Turco; Christian Tschudi; Elisabetta Ullu; Stephen M Beverley
Journal:  PLoS Pathog       Date:  2010-10-28       Impact factor: 6.823

Review 9.  Modulation of dendritic cell function by Leishmania parasites.

Authors:  Lynn Soong
Journal:  J Immunol       Date:  2008-04-01       Impact factor: 5.422

10.  Leishmania major glycosylation mutants require phosphoglycans (lpg2-) but not lipophosphoglycan (lpg1-) for survival in permissive sand fly vectors.

Authors:  Anna Svárovská; Thomas H Ant; Veronika Seblová; Lucie Jecná; Stephen M Beverley; Petr Volf
Journal:  PLoS Negl Trop Dis       Date:  2010-01-12
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