Literature DB >> 11323304

Pre-erythrocytic immunity to Plasmodium falciparum: the case for an LSA-1 vaccine.

J D Kurtis1, M R Hollingdale, A J Luty, D E Lanar, U Krzych, P E Duffy.   

Abstract

A vaccine is urgently needed to stem the global resurgence of Plasmodium falciparum malaria. Vaccines targeting the erythrocytic stage are often viewed as an anti-disease strategy. By contrast, infection might be completely averted by a vaccine against the liver stage, a pre-erythrocytic stage during which the parasite multiplies 10000-fold within hepatocytes. Sterilizing immunity can be conferred by inoculating humans with irradiated pre-erythrocytic parasites, and a recombinant pre-erythrocytic vaccine partially protects humans from infection. Liver-stage antigen-1, one of a few proteins known to be expressed by liver-stage parasites, holds particular promise as a vaccine. Studies of naturally exposed populations have consistently related immune responses against this antigen to protection.

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Year:  2001        PMID： 11323304     DOI： 10.1016/s0169-4758(00)01862-7

Source DB:  PubMed          Journal:  Trends Parasitol        ISSN： 1471-4922


  22 in total

1.  Usefulness of the recombinant liver stage antigen-3 for an early serodiagnosis of Plasmodium falciparum infection.

Authors:  Hyeong-Woo Lee; Sung-Ung Moon; Hye-Sun Ryu; Yeon-Joo Kim; Shin-Hyeong Cho; Gyung-Tae Chung; Khin Lin; Byoung-Kuk Na; Yoon Kong; Kyung-Suk Chung; Tong-Soo Kim
Journal:  Korean J Parasitol       Date:  2006-03       Impact factor: 1.341

2.  Impact of recombinant adenovirus serotype 35 priming versus boosting of a Plasmodium falciparum protein: characterization of T- and B-cell responses to liver-stage antigen 1.

Authors:  Ariane Rodríguez; Jaap Goudsmit; Arjen Companjen; Ratna Mintardjo; Gert Gillissen; Dennis Tax; Jeroen Sijtsma; Gerrit Jan Weverling; Lennart Holterman; David E Lanar; Menzo J E Havenga; Katarina Radosevic
Journal:  Infect Immun       Date:  2008-01-22       Impact factor: 3.441

3.  A prospective analysis of the Ab response to Plasmodium falciparum before and after a malaria season by protein microarray.

Authors:  Peter D Crompton; Matthew A Kayala; Boubacar Traore; Kassoum Kayentao; Aissata Ongoiba; Greta E Weiss; Douglas M Molina; Chad R Burk; Michael Waisberg; Algis Jasinskas; Xiaolin Tan; Safiatou Doumbo; Didier Doumtabe; Younoussou Kone; David L Narum; Xiaowu Liang; Ogobara K Doumbo; Louis H Miller; Denise L Doolan; Pierre Baldi; Philip L Felgner; Susan K Pierce
Journal:  Proc Natl Acad Sci U S A       Date:  2010-03-29       Impact factor: 11.205

Review 4.  Developmental biology of sporozoite-host interactions in Plasmodium falciparum malaria: implications for vaccine design.

Authors:  Javier E Garcia; Alvaro Puentes; Manuel E Patarroyo
Journal:  Clin Microbiol Rev       Date:  2006-10       Impact factor: 26.132

5.  IFNγ Responses to Pre-erythrocytic and Blood-stage Malaria Antigens Exhibit Differential Associations With Past Exposure and Subsequent Protection.

Authors:  Prasanna Jagannathan; Felistas Nankya; Cristina Stoyanov; Ijeoma Eccles-James; Esther Sikyomu; Kate Naluwu; Samuel Wamala; Mayimuna Nalubega; Jessica Briggs; Katherine Bowen; Victor Bigira; James Kapisi; Moses R Kamya; Grant Dorsey; Margaret E Feeney
Journal:  J Infect Dis       Date:  2014-12-17       Impact factor: 5.226

6.  Preclinical evaluation of the safety and immunogenicity of a vaccine consisting of Plasmodium falciparum liver-stage antigen 1 with adjuvant AS01B administered alone or concurrently with the RTS,S/AS01B vaccine in rhesus primates.

Authors:  S Pichyangkul; U Kum-Arb; K Yongvanitchit; A Limsalakpetch; M Gettayacamin; D E Lanar; L A Ware; V A Stewart; D G Heppner; P Mettens; J D Cohen; W R Ballou; M M Fukuda
Journal:  Infect Immun       Date:  2007-10-22       Impact factor: 3.441

7.  Antibodies to pre-erythrocytic Plasmodium falciparum antigens and risk of clinical malaria in Kenyan children.

Authors:  Chandy C John; Aaron J Tande; Ann M Moormann; Peter O Sumba; David E Lanar; Xinan M Min; James W Kazura
Journal:  J Infect Dis       Date:  2008-02-15       Impact factor: 5.226

Review 8.  Antigens for pre-erythrocytic malaria vaccines: building on success.

Authors:  C Speake; P E Duffy
Journal:  Parasite Immunol       Date:  2009-09       Impact factor: 2.280

9.  Stability of interferon-gamma and interleukin-10 responses to Plasmodium falciparum liver stage antigen 1 and thrombospondin-related adhesive protein immunodominant epitopes in a highland population from Western Kenya.

Authors:  Ann M Moormann; Peter Odada Sumba; Daniel J Tisch; Paula Embury; Charles H King; James W Kazura; Chandy C John
Journal:  Am J Trop Med Hyg       Date:  2009-09       Impact factor: 2.345

10.  High levels of antibodies to Plasmodium falciparum liver stage antigen-1 in naturally infected individuals in Myanmar.

Authors:  Hyeong-Woo Lee; Sung-Ung Moon; Yeon-Joo Kim; Shin-Hyeong Cho; Khin Lin; Byoung-Kuk Na; Tong-Soo Kim
Journal:  Korean J Parasitol       Date:  2008-09       Impact factor: 1.341
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