Literature DB >> 11323103

Methylation of the hMLH1, p16, and MDR1 genes in colorectal carcinoma: associations with clinicopathological features.

B A Shannon1, B J Iacopetta.   

Abstract

The methylation status of seven cancer-related genes was investigated in a series of 58 colorectal cancers, 18 of which showed the microsatellite instability (MSI+) phenotype. Methylation of the hMLH1, p16 and MDR1 genes was found in 23, 29 and 28% of tumors, respectively. None of the tumors showed methylation of the TS, ATM, PARP or p21 genes. Methylation of the hMLH1, p16 and MDR1 genes was more frequent and more concordant in MSI+ compared to MSI- tumors (P<0.001) and was also strongly associated with poor histological differentiation (P<0.001). There were trends for associations between methylation at one or more of these loci and proximal tumor location, advanced Dukes' stage and the presence of wild-type p53 (P=0.06 for each).

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Year:  2001        PMID： 11323103     DOI： 10.1016/s0304-3835(01)00431-1

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  6 in total

1.  Characterisation of colorectal cancers showing hypermethylation at multiple CpG islands.

Authors:  M van Rijnsoever; F Grieu; H Elsaleh; D Joseph; B Iacopetta
Journal:  Gut       Date:  2002-12       Impact factor: 23.059

2.  Aberrant p16((INK4a)) methylation is a frequent event in colorectal cancers: prognostic value and relation to mRNA expression and immunoreactivity.

Authors:  Hiroyuki Mitomi; Naoshi Fukui; Nobuho Tanaka; Hideki Kanazawa; Tsuyoshi Saito; Takashi Matsuoka; Takashi Yao
Journal:  J Cancer Res Clin Oncol       Date:  2010-02       Impact factor: 4.553

3.  Impact of the MTHFR C677T polymorphism on colorectal cancer in a population with low genetic variability.

Authors:  Luciano Delgado-Plasencia; Vicente Medina-Arana; Alberto Bravo-Gutiérrez; Julián Pérez-Palma; Hugo Álvarez-Argüelles; Eduardo Salido-Ruiz; Antonia M Fernández-Peralta; Juan J González-Aguilera
Journal:  Int J Colorectal Dis       Date:  2013-02-20       Impact factor: 2.571

Review 4.  MLH1 promoter methylation frequency in colorectal cancer patients and related clinicopathological and molecular features.

Authors:  Xia Li; Xiaoping Yao; Yibaina Wang; Fulan Hu; Fan Wang; Liying Jiang; Yupeng Liu; Da Wang; Guizhi Sun; Yashuang Zhao
Journal:  PLoS One       Date:  2013-03-29       Impact factor: 3.240

5.  Colorectal cancers with both p16 and p14 methylation show invasive characteristics.

Authors:  Kenji Hibi; Hiroshi Nakayama; Masahiko Koike; Yasushi Kasai; Katsuki Ito; Seiji Akiyama; Akimasa Nakao
Journal:  Jpn J Cancer Res       Date:  2002-08

6.  A CpG island hypermethylation profile of primary colorectal carcinomas and colon cancer cell lines.

Authors:  Guro E Lind; Lin Thorstensen; Tone Løvig; Gunn I Meling; Richard Hamelin; Torleiv O Rognum; Manel Esteller; Ragnhild A Lothe
Journal:  Mol Cancer       Date:  2004-10-11       Impact factor: 27.401
  6 in total

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