BACKGROUND/AIMS: The aim of the study was to compare the serum response of regeneration factors and acute phase proteins in patients treated with partial hepatectomy or cryosurgery. METHODS: The responses of serum hepatocyte growth factor (HGF), insulin-like growth factor-I (IGF-I) (free and total), interleukin-6 (IL-6) and the acute phase proteins, C-reactive protein (CRP) and serum amyloid A (SAA) were examined in patients with colorectal liver metastases treated with partial hepatectomy (n = 14) or cryosurgery (n = 10). RESULTS: In both groups, IL-6 peak levels at the end of the operation were followed by peak levels at day 1 for HGF and CRP. SAA peak levels occurred on day 1 (hepatectomy group) and on day 4 (cryo group). The total HGF, IGF-I, and IL-6 responses were comparable in both groups. CRP and SAA responses were higher in the patients treated with cryosurgery than in patients after hepatectomy. Free IGF-I trough levels were lower in partial hepatectomy patients than in cryosurgery patients. CONCLUSIONS: In patients with colorectal liver metastases the responses of the regenerating factors HGF, IGF-I, and IL-6 are comparable to those in patients treated with partial hepatectomy. Upregulation of acute phase protein production is higher in patients after cryosurgery than in patients after partial hepatectomy.
BACKGROUND/AIMS: The aim of the study was to compare the serum response of regeneration factors and acute phase proteins in patients treated with partial hepatectomy or cryosurgery. METHODS: The responses of serum hepatocyte growth factor (HGF), insulin-like growth factor-I (IGF-I) (free and total), interleukin-6 (IL-6) and the acute phase proteins, C-reactive protein (CRP) and serum amyloid A (SAA) were examined in patients with colorectal liver metastases treated with partial hepatectomy (n = 14) or cryosurgery (n = 10). RESULTS: In both groups, IL-6 peak levels at the end of the operation were followed by peak levels at day 1 for HGF and CRP. SAA peak levels occurred on day 1 (hepatectomy group) and on day 4 (cryo group). The total HGF, IGF-I, and IL-6 responses were comparable in both groups. CRP and SAA responses were higher in the patients treated with cryosurgery than in patients after hepatectomy. Free IGF-I trough levels were lower in partial hepatectomy patients than in cryosurgery patients. CONCLUSIONS: In patients with colorectal liver metastases the responses of the regenerating factors HGF, IGF-I, and IL-6 are comparable to those in patients treated with partial hepatectomy. Upregulation of acute phase protein production is higher in patients after cryosurgery than in patients after partial hepatectomy.
Authors: Simon A W G Dello; Johanne G Bloemen; Marcel C G van de Poll; Ronald M van Dam; Jan H M B Stoot; Maartje A J van den Broek; Wim A Buurman; Marc H A Bemelmans; Steven W M Olde Damink; Cornelis H C Dejong Journal: HPB (Oxford) Date: 2011-03-07 Impact factor: 3.647
Authors: Joseph P Erinjeri; Contessa T Thomas; Alaiksandra Samoilia; Martin Fleisher; Mithat Gonen; Constantinos T Sofocleous; Raymond H Thornton; Robert H Siegelbaum; Anne M Covey; Lynn A Brody; William Alago; Majid Maybody; Karen T Brown; George I Getrajdman; Stephen B Solomon Journal: J Vasc Interv Radiol Date: 2013-04-10 Impact factor: 3.464
Authors: M H M G M den Brok; R P M Sutmuller; S Nierkens; E J Bennink; C Frielink; L W J Toonen; O C Boerman; C G Figdor; T J M Ruers; G J Adema Journal: Br J Cancer Date: 2006-09-05 Impact factor: 7.640