Literature DB >> 11320029

Sensitivity and specificity of tests to detect eye disease in an older population.

R Q Ivers1, B Optom, P Macaskill, R G Cumming, P Mitchell.   

Abstract

OBJECTIVE: To compare the ability of tests of visual function to detect the presence of eye disease.
DESIGN: Cross-sectional study. PARTICIPANTS: Three thousand six hundred fifty-four of 4433 (82.4%) eligible residents of an area near Sydney aged 49 years and older had a detailed eye examination, including retinal and lens photography and subsequent grading of eye disease, tests of presenting and corrected visual acuity, contrast sensitivity, screening visual field and intraocular pressure. MAIN OUTCOME MEASURES: Receiver operator characteristic (ROC) curves were created and area under the curve compared for each vision test. Sensitivity and specificity were calculated for each test.
RESULTS: No single vision test predicted the presence of eye disease with any consistency. Best-corrected visual acuity or contrast sensitivity had the highest area under the ROC curve for most eye diseases examined but had poor sensitivity and specificity. For glaucoma and diabetic retinopathy there was no difference in area under the curve for any of the tests examined, and no test had a good balance of sensitivity and specificity. Screening tests (performed with presenting correction) did not perform as well as nonscreening tests (those carried out after refraction with best correction).
CONCLUSIONS: Current vision tests are not particularly good at detecting eye disease compared with the "gold standard" of a full eye examination performed by an ophthalmologist. Further work in this area should be carried out before vision screening programs can be recommended for implementation among older people.

Entities:  

Mesh:

Year:  2001        PMID: 11320029     DOI: 10.1016/s0161-6420(00)00649-7

Source DB:  PubMed          Journal:  Ophthalmology        ISSN: 0161-6420            Impact factor:   12.079


  10 in total

1.  Multifocal pupillography identifies retinal dysfunction in early age-related macular degeneration.

Authors:  Faran Sabeti; Andrew C James; Rohan W Essex; Ted Maddess
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2013-02-08       Impact factor: 3.117

2.  Dichoptic multifocal visual evoked potentials identify local retinal dysfunction in age-related macular degeneration.

Authors:  Faran Sabeti; Andrew C James; Rohan W Essex; Ted Maddess
Journal:  Doc Ophthalmol       Date:  2012-12-13       Impact factor: 2.379

3.  Predictive value of screening tests for visually significant eye disease.

Authors:  Laura J Kopplin; Steven L Mansberger
Journal:  Am J Ophthalmol       Date:  2015-06-04       Impact factor: 5.258

4.  Correlation between peripapillary macular fiber layer thickness and visual acuity in patients with open-angle glaucoma.

Authors:  Kazuko Omodaka; Toru Nakazawa; Yu Yokoyama; Hiroshi Doi; Nobuo Fuse; Kohji Nishida
Journal:  Clin Ophthalmol       Date:  2010-07-21

5.  Optical coherence tomography measurement of macular and nerve fiber layer thickness in normal and glaucomatous human eyes.

Authors:  Viviane Guedes; Joel S Schuman; Ellen Hertzmark; Gadi Wollstein; Anthony Correnti; Ronald Mancini; David Lederer; Serineh Voskanian; Leonardo Velazquez; Helena M Pakter; Tamar Pedut-Kloizman; James G Fujimoto; Cynthia Mattox
Journal:  Ophthalmology       Date:  2003-01       Impact factor: 12.079

6.  The papilla as screening parameter for early diagnosis of glaucoma.

Authors:  Georg Michelson; Simone Wärntges; Joachim Hornegger; Berthold Lausen
Journal:  Dtsch Arztebl Int       Date:  2008-08-25       Impact factor: 5.594

7.  Relationship between visual field loss and contrast threshold elevation in glaucoma.

Authors:  C M Tochel; J S Morton; J L Jay; J D Morrison
Journal:  BMC Ophthalmol       Date:  2005-09-13       Impact factor: 2.209

8.  Comparison of Peristat Online Perimetry with the Humphrey Perimetry in a Clinic-Based Setting.

Authors:  Eugene A Lowry; Jing Hou; Lauren Hennein; Robert T Chang; Shan Lin; Jeremy Keenan; Sean K Wang; Sean Ianchulev; Louis R Pasquale; Ying Han
Journal:  Transl Vis Sci Technol       Date:  2016-07-19       Impact factor: 3.283

9.  Correlation of Central Versus Peripheral Macular Structure-Function With Acuity in Age-Related Macular Degeneration.

Authors:  Faran Sabeti; Jo Lane; Emilie M F Rohan; Bhim B Rai; Rohan W Essex; Elinor McKone; Ted Maddess
Journal:  Transl Vis Sci Technol       Date:  2021-02-05       Impact factor: 3.283

10.  Role of advanced technology in the detection of sight-threatening eye disease in a UK community setting.

Authors:  Bruno R Fidalgo; Priya Dabasia; Anish Jindal; David F Edgar; Irene Ctori; Tunde Peto; John G Lawrenson
Journal:  BMJ Open Ophthalmol       Date:  2019-12-04
  10 in total

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