Literature DB >> 1131817

Identification of phosphorodiamidic acid mustard as a human metabolite of cyclop hosphamide.

C Fenselau, M N Kan, S Billets, M Colvin.   

Abstract

An active metabolite of cyclophosphamide, N,N-bis(2-chloroethyl)phosphorodiamidic acid, has been confirmed as a circulating and excreted metabolite in patients receiving the drug in therapy, by selected ion monitoring on a gas chromatograph mass spectrometer.

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Year:  1975        PMID： 1131817

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  5 in total

1.  Preclinical pharmacokinetics and stability of isophosphoramide mustard.

Authors:  J J Zheng; K K Chan; F Muggia
Journal:  Cancer Chemother Pharmacol       Date:  1994       Impact factor: 3.333

2.  [Permeability of N,N-bis(2-chloroethyl)-diamido-phosphoric-acid into tumor cells (author's transl)].

Authors:  U Lenssen; H J Hohorst
Journal:  J Cancer Res Clin Oncol       Date:  1979-02-19       Impact factor: 4.553

Review 3.  Clinical pharmacokinetics of commonly used anticancer drugs.

Authors:  F M Balis; J S Holcenberg; W A Bleyer
Journal:  Clin Pharmacokinet       Date:  1983 May-Jun       Impact factor: 6.447

4.  Kinetics of hydrolysis in vitro of nornitrogen mustard, a metabolite of phosphoramide mustard and cyclophosphamide.

Authors:  K Hemminki; A Alhonen; E Linkola; A Hesso
Journal:  Arch Toxicol       Date:  1987-12       Impact factor: 5.153

5.  Metabolite Profiling in Anticancer Drug Development: A Systematic Review.

Authors:  Nadda Muhamad; Kesara Na-Bangchang
Journal:  Drug Des Devel Ther       Date:  2020-04-09       Impact factor: 4.162
  5 in total

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