AIMS/HYPOTHESIS: Obesity is a complex trait influenced by multiple genes. We evaluated linkage in three regions of human chromosome 10 previously linked to obesity-related phenotypes. METHODS: We conducted non-parametric linkage analysis of obesity-related phenotypes in cohorts of 170 European-American and 43 African-American families having extremely obese and normal weight subjects. RESULTS: We found support for linkage of an obesity phenotype (BMI > or = 27 kg/m2) in both cohorts, as well as in a combined analysis (European-American cohort, Z = 1.90, p = 0.03; African-American cohort, Z = 2.25, p = 0.014; combined cohort, Z = 2.55, p = 0.005). CONCLUSION/ INTERPRETATION: These results confirm previous reports of linkage in French and German families. The consistency of results across these four cohorts supports the localization of a quantitative trait locus influencing obesity to human chromosome region 10p12.
AIMS/HYPOTHESIS: Obesity is a complex trait influenced by multiple genes. We evaluated linkage in three regions of human chromosome 10 previously linked to obesity-related phenotypes. METHODS: We conducted non-parametric linkage analysis of obesity-related phenotypes in cohorts of 170 European-American and 43 African-American families having extremely obese and normal weight subjects. RESULTS: We found support for linkage of an obesity phenotype (BMI > or = 27 kg/m2) in both cohorts, as well as in a combined analysis (European-American cohort, Z = 1.90, p = 0.03; African-American cohort, Z = 2.25, p = 0.014; combined cohort, Z = 2.55, p = 0.005). CONCLUSION/ INTERPRETATION: These results confirm previous reports of linkage in French and German families. The consistency of results across these four cohorts supports the localization of a quantitative trait locus influencing obesity to human chromosome region 10p12.
Authors: Chuanhui Dong; Wei-Dong Li; Frank Geller; Lei Lei; Ding Li; Olga Y Gorlova; Johannes Hebebrand; Christopher I Amos; Robert D Nicholls; R Arlen Price Journal: Am J Hum Genet Date: 2005-01-12 Impact factor: 11.025
Authors: Hannah C Cox; Claire Bellis; Rod A Lea; Sharon Quinlan; Roger Hughes; Thomas Dyer; Jac Charlesworth; John Blangero; Lyn R Griffiths Journal: Hum Hered Date: 2009-04-01 Impact factor: 0.444